Category | Feature | Value | References |
Epidemiology | Primary cardiac lymphoma | 1% - 2% of all cardiac tumors | [1] [2] [17] |
Secondary cardiac involvement | Up to 20% of NHL cases | ||
Age at diagnosis | Median | 55 - 65 years | [3] [4] [5] |
Range | 10 - 83 years | ||
Sex | Male | 65% - 85% | [3] [4] |
Female | 15% - 35% | ||
Presenting features | Heart failure | 31% - 78% | [3] [4] [9] [10] [32] |
Chest pain | 19% - 46% | ||
Arrhythmia | 8% - 56% | ||
Constitutional symptoms | 7% - 26% | ||
SVC syndrome | 5% - 15% | ||
Location and involvement | Right atrium | 66% - 77% | [4] [32] |
Right ventricle | 25% - 37% | ||
Left atrium | 12% - 30% | ||
Left ventricle | 2% - 21% | ||
Septum | 2% - 41% | ||
Pericardial effusion | 30% - 58% | ||
Histology | DLBCL | 71% - 92% | [3] [4] [32] |
Burkitt | 7% - 8% | ||
CLL/SLL | 4% - 8% | ||
T cell | 3% - 5% | ||
Other or NOS | Up to 10% | ||
Treatment | Chemotherapy | 52% - 89% | [3] [4] [32] |
Surgery | 16% - 28% | ||
Radiation | 8% - 20% | ||
Combination therapy | 12% - 23% | ||
Outcomes | Median OS | 3 - 63 months | [3] [4] |