Publication, year	Patient age/sex	Orthopedic surgery	DVT prophylaxis	POD at diagnosis	Platelet nadir	Thrombotic events	PF4 IgG OD	Functional assay
Warkentin et al., 2007	48 F	Bilateral TKA	Fondaparinux	10	39,000	Bilateral adrenal hemorrhage Right lower extremity DVT	1.87	+SRA
Jay et al., 2008	69 F	Right TKA	Warfarin	9	11,000	Bilateral adrenal hemorrhage Right lower extremity DVT Digital infarcts	1.89	+SRA
Pruthi et al., 2009	61 F	Right TKA	Warfarin	10	15,000	Bilateral adrenal hemorrhage Bilateral DVTs/PEs	2.30	+SRA
Salem et al., 2010	67 M	Left TKA	Fondaparinux	9	35,000	Bilateral DVTs Ischemic CVA	2.803	ND
Mallik et al., 2011	60 M	Bilateral TKA	Warfarin	10	15,000	Bilateral DVTs	3.0	+SRA
Burch et al., 2012	63 M 63 M	Right TKA Right TKA	Fondaparinux Fondaparinux	18 12	50,000 38,000	DVT/PE IVC thrombosis Iliac artery thrombosis Splenic and left renal infarcts	2.807 3.081	+SRA +SRA
Ketha et al., 2013	61 F 60 F 65 M 71 F	TKA TKA TKA TKA	Warfarin Warfarin Warfarin Warfarin	9 - 15 9 - 15 9 - 15 9 - 15	15,000 81,000 115,000 20,000	Bilateral adrenal hemorrhage DVT Bilateral adrenal hemorrhage DVT Bilateral adrenal hemorrhage DVT Bilateral adrenal hemorrhage DVT	Elevated Elevated Elevated Elevated	+SRA +SRA +SRA +SRA
Warkentin et al., 2014	54 F	Shoulder arthroplasty	None	15	37,000	Right lower extremity DVT Ischemic CVA	2.89	+SRA
Warkentin et al., 2015	ND	TKA	Apixaban	13	37,000	Bilateral adrenal hemorrhage DVT/PE IVC thrombosis	3.02	+SRA
Elshoury et al., 2015	48 F	Left TKA	Aspirin	10	15,000	Bilateral adrenal hemorrhage Bilateral PEs	Elevated	+SRA
Baker et al., 2017	72 F	Left TKA	Aspirin	12	25,000	Bilateral DVTs/PEs	2.97	+SRA
DeBaun et al., 2017	68 M	Bilateral TKA	Rivaroxaban	16	43,000	Bilateral adrenal hemorrhage Right lower extremity DVT IVC and renal vein thrombosis	3.037	+HITIA