Authors | Random | Allocation | Double-blind | FSD | FSFI | Drop out (%) | Adverse effects |
Ito et al. 2006 [7] | − | − | + | HSDD | FSFI modified | 0 | No significant difference in adverse effects |
Chedraui et al. 2006 [8] | − | − | + | + | KI | 11.7 | Not described |
Akhtari et al. 2014 [9] | + | + | + | HSDD | + | 10.4 | Only one patient reported grade 1 abdominal cramp. |
Rao et al. 2015 [10] | + | + | + | HSSD | + | 0 | No significant difference in adverse effects |
Zeinalzadeh et al. 2016 [11] | + | + | + | HSSD | + | 10.7 | Not described |
Postigo et al. 2016 [13] | − | − | + | FSD | SQ-F, FIEI | 0 | No significant difference in adverse effects |
De Souza et al. 2016 [12] | + | − | + | HSDD | + | 20 | Not described |
Vale et al. 2017 [14] | − | − | + | HSDD | + | 37.5 | Not described |
Bernorio et al. 2018 [15] | + | + | + | FSD | + | 3.3 | Both products were very well tolerated |
Caruso et al. 2018 [20] | + | − | − | HSDD | + | 26.9 | Not described |
Caputo et al. 2018 [21] | − | − | − | FSD | + | 3.3 | Not described |
DRUG-INDUCED FSD (DIFSD) | |||||||
Meston et al. 2008 [16] | − | − | + | FSD + DIFSD | + | 19.1 | Not described |
Kashani et al. 2012 [17] | − | − | + | DIFSD | + | 10.5 | Described with no differences |
Farnia et al. 2015 [18] | + | − | + | DIFSD | + | 0 | No side effects |
Farnia et al. 2017 [19] | + | − | + | DIFSD | + | 0 | Not described |