Souza et al. 2016 [12]

RCT

NCT01975694

45 women with HSDD

Average age: 53

Ÿ Tribulus terrestris^c 750 mg/day (n = 20)

Ÿ Placebo (n = 16)

Ÿ 12 weeks

Ÿ Primary: efficacy of HSDD

Ÿ Secondary: testosterone

Improvements in total FSFI score and most domains, increase of free and bioavailable testosterone

NO differences respecting placebo

Vale et al. 2018 [14]

RCT

NCT01971099

40 women with HSDD

Age: 18 - 44

Ÿ Tribulus terrestris^c, 750 mg/day (n = 20)

Ÿ Placebo (n = 20)

Ÿ 120 days

Ÿ Primary: efficacy of HSDD

Ÿ Secondary: testosterone

Improvements in total FSFI score and most domains, increase of free and bioavailable testosterone

NO differences respecting placebo

Bernorio et al. 2018 [15]

RCT Pilot study

60 women with FSD

Age: 18 - 60

Ÿ Visnadine spray (n = 30)

Ÿ Placebo (n = 30)

Ÿ 30 days

Efficacy on FSD

Improvements in sexual function (FSFI) in women with/without FSD respect to placebo (p < 0.05)

Caruso et al. 2018 [21]

RCT crossover study

38 women with HSDD

Age: 25 - 40

Ÿ Visnadine spray on demand (n = 30)

Ÿ Visnadine spray daily (n = 30)

Ÿ 60 days

Efficacy on HSDD

Both improved HSDD (p  <  0.001)

Caputo et al. 2018 [21]

RCT pilot study

69 women with FSD

Average Age: 35 - 38

Ÿ Visnadine oil (n = 30)

Ÿ Placebo (n = 30)

Ÿ 8 weeks

Efficacy on FSD

Improvements on FSFI (p < 0.05)

Meston et al. 2008 [16]

RCT

63 women with FSD + 36 with DFSD (antidepressant)

Age: 18 - 65.

Ÿ Ginkgo biloba^f 300 mg/day (n = 19)

Ÿ Ginkgo biloba + sex therapy (n = 14)

Ÿ Sex therapy (n = 19)

Ÿ Placebo (n = 16 )

Ÿ 8 weeks

Efficacy on DIFSD

Ginkgo biloba + sex therapy increased desire respect placebo (p < 0.05), but not Ginkgo biloba alone

Sex therapy alone enhanced orgasm function respect placebo (p < 0.05).

Kashani et al. 2013 [17]

RCT

138711121556N3

38 women with DFSD (fluoxetine)

Age:18 - 45

Ÿ Saffron^g 30 mg/day (n = 19)

Ÿ Placebo (n = 19)

Ÿ 4 weeks

Efficacy on DIFSD

Improvement in total FSFI (p < 0.001), arousal (p = 0.028), lubrication (p = 0.035), and pain (p = 0.016) but not in desire, satisfaction and orgasm.

Farnia et al. 2015 [18]

RCT

IRCT2013100114333N9

61 women with DFSD (SSRI)

Age: 34

Ÿ Rosa damascena oil^h 2 ml/day (n = 31)

Ÿ Placebo (n = 31)

Ÿ 8 weeks

Efficacy on DIFSD

No Improvements on FSFI compared to placebo

Farnia et al. 2017 [19]

RCT IRCT2015091523705N2

50 women with DFSD (methadone)

Age: 38.8

Ÿ Rosa damascena oil^h 2 ml/day (n = 25)

Ÿ Placebo (n = 25)

Ÿ 8 weeks

Efficacy on DIFSD

Sex hormones

Improvements on FSFI (p < 0.05) and sex hormones compared to placebo