Authors | Method | Population | Intervention | Objective | Main results |
Ito et al. 2006 [7] | RCT | 108 women with HSDD Age: 22 - 73 | ArginMaxa (n = 55) Placebo (n = 53) 8 weeks | Efficacy on HSDD | Improvement in postmenopausal women (p = 0.008) |
Chedraui et al. 2006 [8] | Crossover RCT | 60 women with FSD Age: >40 | Red cloverb, 80 mg/day (n = 30) Placebo (n = 30) 3 + 3 months | Efficacy on FSD | Improvement in dyspareunia, vaginal dryness and decreased libido (p < 0.05) |
Akhtari et al. 2014 [9] | RCT IIRCT20121111111425N1 | 67 women with HSDD Average age: 36 | Tribulus terrestrisc, 750 mg/day (n = 33) Placebo (n = 34) 4 weeks | Efficacy on HSDD | Improvement on total FSFI (p < 0.001), desire (p < 0.001), arousal (p = 0.037), lubrication (p < 0.001), satisfaction (p < 0.001) pain (p = 0.041) |
Rao et al. 2015 [10] | RCT 12611001031954. | 80 women with HSDD Average Age: 34.9 (20 - 49) | Trigonella foenum- graecumd seed extract (Libifem) 600 mg/day (n = 40) Placebo (n = 40) 2 menstrual cycles | Primary: efficacy on HSDD Secondary: E2 and testosterone | Improvement in sexual desire and arousal vs placebo (p < 0.05) |
Zeinalzadeh et al. 2016 [11] | RCT 201205219818N1 | 125 women with HSSD Age:18 - 40 | Elaeagnus angustiflorae 4.5 g (n = 41) Sildenafil 50 mg (n = 42) Placebo (n = 42) 4 weeks | Primary: efficacy on HSDD Secondary: TSH and prolactin | Only sildenafil decreased anxiety resulting from sexual dysfunction |
Postigo et al. 2016 [13] | RCT ISSN0100-7203 | 60 women with FSD. Average age: 55 | Tribulus terrestrisc 750 mg/day (n = 30) Placebo (n = 30) 90 days | Efficacy on FSD | Improvements in all domains but NO differences respecting placebo |