Authors

Method

Population

Intervention

Objective

Main results

Ito et al. 2006 [7]

RCT

108 women with HSDD

Age: 22 - 73

Ÿ ArginMaxa (n = 55)

Ÿ Placebo (n = 53)

Ÿ 8 weeks

Efficacy on HSDD

Improvement in postmenopausal women (p = 0.008)

Chedraui et al. 2006 [8]

Crossover RCT

60 women with FSD

Age: >40

Ÿ Red cloverb, 80 mg/day (n = 30)

Ÿ Placebo (n = 30)

Ÿ 3 + 3 months

Efficacy on FSD

Improvement in dyspareunia, vaginal dryness and decreased libido (p < 0.05)

Akhtari et al. 2014 [9]

RCT

IIRCT20121111111425N1

67 women with HSDD

Average age: 36

Ÿ Tribulus terrestrisc, 750 mg/day (n = 33)

Ÿ Placebo (n = 34)

Ÿ 4 weeks

Efficacy on HSDD

Improvement on total FSFI (p < 0.001), desire (p < 0.001), arousal (p = 0.037), lubrication (p < 0.001), satisfaction (p < 0.001) pain (p = 0.041)

Rao et al. 2015 [10]

RCT

12611001031954.

80 women with HSDD

Average Age: 34.9 (20 - 49)

Ÿ Trigonella foenum- graecumd seed extract (Libifem) 600 mg/day (n = 40)

Ÿ Placebo (n = 40)

Ÿ 2 menstrual cycles

Ÿ Primary: efficacy on HSDD

Ÿ Secondary: E2 and testosterone

Improvement in sexual desire and arousal vs placebo (p < 0.05)

Zeinalzadeh et al. 2016 [11]

RCT

201205219818N1

125 women with HSSD

Age:18 - 40

Ÿ Elaeagnus angustiflorae 4.5 g (n = 41)

Ÿ Sildenafil 50 mg (n = 42)

Ÿ Placebo (n = 42)

Ÿ 4 weeks

Ÿ Primary: efficacy on HSDD

Ÿ Secondary: TSH and prolactin

Only sildenafil decreased anxiety resulting from sexual dysfunction

Postigo et al. 2016 [13]

RCT

ISSN0100-7203

60 women with FSD.

Average age: 55

Ÿ Tribulus terrestrisc 750 mg/day (n = 30)

Ÿ Placebo (n = 30)

Ÿ 90 days

Efficacy on FSD

Improvements in all domains but NO differences respecting placebo