Author(s) Year | Case number | Results | Conclusions | |
1. Romantic love | ||||
Takahashi et al. 2015 [23] | 6 men and 4 women | visual stimulation of partner’s photo increased the dopamine dynamics at the mOFC and mPC in lovers who committed romantic relationship for 2 to 125 months | dopaminergic D2/D3 modulates the rewarding experience of romance in both early and late phase of romantic relationship | |
Marazziti et al. 2016 [30] | 30 in-lovers less than and 30 in-lovers more than 6 months relationship; women and men are equal in both groups | lymphocytic DAT decreased whereas DA in early phase than late phase of relationship | increase of DA though a suppression of DAT occurs in early phase of relationship | |
Marazziti et al. 1999 [31] | 20 in-lovers less than 6 months relationship, 20 OCD patients, 20 non-lover | platelet SERT decreased in in-lovers and OCD patients than non-lovers | increase of 5HT though a suppression of SERT occurs in early phase of relationship | |
Marazziti et al. 2014 [37] | 123 women and 69 men with depression | SSRIs had a significant negative impact on the feelings of love and attachment towards the partner especially in men, while women taking TCAs complained of more sexual adversity than men. | SSRI can disturb romantic love | |
Syvertsen et al. 2015 [39] | 161 couples | methamphetamine usage in female sex workers reduced the love score to their male intimate partners and vice versa. | romantic love is vulnerable to central modulating drugs | |
2. Romantic relationship | ||||
Masarik et al. 2014 [32] | 352 adolescence | ANKK1/DRD2 and DAT polymorphism independently predict a continuity of hostility from parenting to partner, whereas the DRD4 polymorphism of positive engagement | genetic background relates in human response to environmental stress in both positive and negative emotion. | |
Raby et al. 2013 [33] | 74 female and 69 male adolescence | attachment continuity relates to OXTR G/G genotype only | infantile attachment to romantic attachment is modulated by the OXTR but not DRD4 or 5-HTTLPR | |