|
|
| Onset age of lipodystrophy | Distribution of adipose tissue | Clinical and biological parameters |
Genetic | Generalized | BSCL1 BSCL2 BSCL3 | Childbirth or early childhood | Complete lipoatrophy | Acanthosis nigricans Dyslipidemia Diabetes |
Partial | FPLD2 | Puberty | Lipoatrophy of the limbs and buttocks, increase of fat in the face and neck | ||
Metabolic laminopathy | Puberty | Light lipodystrophy or absent | |||
FPLD3 | Puberty | Lower body lipoatrophy | Hypertension Acanthosis nigricans Dyslipidemia Diabetes | ||
AKT2-linked |
| Partial lipodystrophy | Hypertension Acanthosis nigricans Diabetes | ||
Acquired | Generalized | Lawrence Syndrome | Childhood or adulthood | Complete lipoatrophy | Sometimes panniculitis, Acanthosis nigricans Dyslipidemia Diabetes |
Partial | Barraquer-Simmons Syndrome | Adolescence or beginning of adulthood | Lipoatrophy in upper part of the body Lower body fat accumulation | Infrequent metabolic alterations Sometimes low C3 and membranoproliferative glomerulonephritis | |
Hypercortisolism-related | Usually adulthood | Lower lipoatrophy Fat accumulation in the upper part of the body | Dyslipidemia Frequently with diabetes | ||
Generalized or Partial | HIV-related | Usually adulthood | Peripheral lipoatrophy Central lipoatrophy or fat accumulation | Dyslipidemia Sometimes diabetes |