Characteristic | Colonized (n = 125) | Not Colonized (n = 331) | Colonized vs. Not Colonized | ||||
Linezolid (n = 52) | Vancomycin (n = 73) | P Value | Linezolid (n = 187) | Vancomycin (n = 144) | P Value | P Value | |
Age, Mean (SD), y | 45.9 (19.4) | 49.7 (16.3) | 0.24 | 49.8 (17.4) | 49.3 (19.1) | 0.80 | 0.44 |
Gender, Male, n (%) | 31 (59.6) | 49 (67.1) | 0.45 | 100 (53.5) | 78 (54.2) | 0.91 | 0.06 |
Race, n (%) White Black Asian Other |
35 (67.3) 10 (19.2) 0 7 (13.5) |
50 (68.5) 16 (21.9) 0 7 (9.6) |
0.77 |
135 (72.2) 26 (13.9) 2 (1.1) 24 (12.8) |
95 (66.0) 16 (11.1) 2 (1.4) 31 (21.5) |
0.19 |
0.06 |
Weight, kg (SD) | 89.8 (36.9) | 83.8 (23.6) | 0.27 | 85.8 (24.8) | 82.1 (29.1) | 0.21 | 0.47 |
Prior Hospitalization, n (%) | 23 (44.2) | 28 (38.4) | 0.58 | 77 (41.2) | 63 (43.8) | 0.66 | 0.83 |
Route of Initial Treatment, n (%) IV Oral |
27 (51.9) 25 (48.1) |
73 (100) 0 | <0.01 |
103 (55.1) 84 (44.9) |
144 (100) 0 |
<0.01 |
0.27 |
Concomitant Gram-Negative Coverage, n (%) | 29 (55.8) | 35 (47.9) | 0.47 | 80 (42.8) | 68 (47.2) | 0.44 | 0.25 |
Corticosteroid Receipt, n (%) | 5 (9.6) | 5 (6.8) | 0.74 | 10 (5.3) | 11 (7.6) | 0.50 | 0.54 |
Immunosuppressant Receipt, n (%) | 0 | 0 |
| 1 (0.5) | 1 (0.7) | 1.0 | 1.0 |
Primary Diagnosis, n (%) Abscess Ulcer Surgical Wound Other |
30 (57.7) 7 (13.5) 12 (23.1) 3 (5.8) |
46 (63.0) 11 (15.1) 14 (19.2) 2 (2.7) |
0.77 |
88 (47.1) 33 (17.6) 39 (20.9) 27 (14.4) |
64 (44.4) 23 (16.0) 38 (26.4) 19 (13.2) |
0.70 |
<0.01 |
Comorbidities Diabetes Cardiac Immune System Disorders Psychiatric Disorders Respiratory Disorders Vascular Disorders |
16 (30.8) 11 (21.2) 11 (21.2) 20 (38.5) 10 (19.2) 21 (40.4) |
27 (37.0) 14 (19.2) 11 (15.1) 26 (35.6) 12 (16.4) 32 (43.8) |
0.57 0.82 0.48 0.85 0.81 0.72 |
56 (29.9) 45 (24.1) 40 (21.4) 72 (38.5) 45 (24.1) 101 (54.0) |
41 (28.5) 35 (24.3) 26 (18.1) 41 (28.5) 32 (22.2) 63 (43.8) |
0.80 1.0 0.49 0.06 0.79 0.08 |
0.30 0.38 0.69 0.66 0.20 0.48 |
Isolated Pathogens, n (%) MRSA Only MRSA Mixed Infection |
36 (69.2) 16 (30.8) |
53 (72.6) 20 (27.4) |
0.69 |
142 (75.9) 45 (24.1) |
105 (72.9) 39 (27.1) |
0.61 |
0.48 |