| Upper GI Bleed | Lower GI bleed | |
| Location | Proximal to Ligament of Treitz (esophagus, stomach, or duodenum) | Distal to Ligament of Treitz (jejunum, ileum, colon, rectum) |
| Symptoms | Hematemesis Coffee-ground emesis Melena Hematochezia (very brisk bleeding) | Hematochezia Melena (SI, ascending colon) |
| Causes | Age-specific, associated conditions (PUD bleeding, varices, erosive esophagitis, and vomiting-induced hematemesis) | Crohn’s disease, ulcerative colitis, hemorrhoids, anal fissures, and Meckel diverticulum |
| Diagnostics | Esophagogastroduodenoscopy | Colonoscopy |