34

Different types of metastatic/recurrent cancers

33

mEHT + radiotherapy

CR = 2 (6.1%), Very good PR = 5 (15.2%), PR = 13 (39.4%), SD = 9 (27.3%), PD = 4 (12.1%). Three patients (9.1%) developed autoimmune toxicities. All these three ptients had long-lasting abscopal responses outside the irradiated area.

Chi, Mehta, et al. 2020 [173]

35

Advanced gastric cancer

24

mEHT + chemotherapy + ketogenic diet + oxygen therapy

CR = 22 (88%) Mean follow-up = 23.9 m, mean OS = 39.5 m, mean PFS = 36.5 m,

Iyikesici, 2020b [174] ,

36

Various

mEHT + chemotherapy

The feasibility and success of oncothermia is proven.

Fiorentini 2020 [175]

37

GBM

mEHT + chemotherapy

The feasibility and success of oncothermia is proven.

Van Gool 2021 [176]

38

Rectal cancer

120

mEHT + radiotherapy

+ surgery

In mEHT group, 80.7% showed down-staging

compared with 67.2% in non-mEHT group.

Kim 2021 [177] ,

39

Gliomas

164

mEHT + chemotherapy

+ radiotherapy

CR + PR is 41.4% for mEHT and 33.4% for conventional therapies.

Fiorentini 2020 [178]

40

Gastrointestinal cancer

34

mEHT + chemotherapy

The feasibility and success of oncothermia is proven.

Garay 2020 [179]

41

Ovarian, cervical cancer

mEHT + chemotherapy

+ radiotherapy

The feasibility and success of oncothermia is proven.

Wookyeom 2018 [180] ,

42

Breast cancer

13

mEHT + chemotherapy

+ surgery

The feasibility and success of oncothermia is proven.

Szasz AM 2020 [181]

43

Cervical cancer

38

mEHT + chemotherapy

Cox-regression for CTx + mEHT study-group, (Rs-variable time-ratio of start of mEHT compared to OS (overall survival) Coefficient = 6.1, CI (95%) = 7.96; StErr = 4.06, p = 0.13, Hazard = 449.

Lee 2020 [81]

44

Various sites

277

mEHT + chemotherapy

52% of the entire group was subjected to result analysis. 48% was not traceable. The result of the 52% was 21.5% PR, 36% SD, 28.9% PD, and 12.6% exitus. So 58.5% of the patients showed either stable disease or partial remission.

Lee 2013 [182]

45

Various sites

784

mEHT + chemotherapy

+ radiotherapy + surgery

Preliminary results show promising survival trajectories. mEHT is a safe treatment with very few adverse events or side effects, allowing patients to maintain a higher quality of life.

Parmar 2020 [183]

46

Various sites

mEHT + chemotherapy

+ radiotherapy

Planned trial

Arrojo 2020 [184]

47

Various sites

mEHT + chemotherapy

+ radiotherapy

The feasibility and success of oncothermia is proven.

Szasz AM 2019 [143]

48

Brain tumor

54

mEHT + chemotherapy

mEHT strongly and significantly enhances the efficacy of the ddTMZ 21/28 d regimen (p = 0.011), with a maximum attainable MST of 10.10 months (95%CI 9.10 to 11.10).

Roussakow 2017

[185]