Biochemical profiling^a

IC₅₀ (nmol/l)^b

K_i [ATP] (nmol/l)^b

CDK4/cyclin D1

2.0 ± 0.4 (n = 5)

0.6 ± 0.3 (n = 2)

CDK6/cyclin D1

9.9 (n = 1)

2.4 ± 1.2 (n = 2)

CDK1/cyclin B1

1627 ± 666 (n = 5)

-

CDK2/cyclin E

504 ± 298 (n = 3)

-

CDK9/cyclin T1

57 ± 42 (n = 4)

-

CDK7/Mat1/cyclin H1

3910 ± 2410 (n = 4)

-

PIM1

50 (n = 1)

-

PIM2

3400 (n = 1)

-

ERK1

>20,000 (n = 1)

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