| Ref. | Study Type/Acronym | Intervention | Population/Sample Size | Results/Benefits | Adverse Effects |
| [31] | Randomized DB PC Trial | (800IU Vitamin E, 1g Vitamin C and 200g allopurinol) daily | 54 women with severe pre-eclampsia (24 - 32 weeks pregnancy) | Do not encourage the routine use of antioxidants against pre-eclampsia | Increase in acne, transient weakness and skin rash |
| [30] | Multicenter RCT/(INTAPP) | 1g vitamin C and 400 IU of Vitamin E or placebo daily | 2647 women from 27 centers | No reduction in the rate of pre-eclampsia | increased fetal loss and preterm rupture of membrane |
| [32] | Multicenter PC Trial | 1g vitamin C and 400 IU of Vitamin E or placebo daily | 687 women (14 - 22 weeks pregnancy) | No reduction in the rate of pre-eclampsia high-risk pregnant women with low nutritional status | Not Reported |
| [33] | SR | Antioxidant (with Vitamin C, E, selenium and lycopene) | 10 RCT with 6533 women (12 - 28 weeks pregnancy) | No reduction in the risk of pre-eclampsia and its complications | Not Reported |
| [34] | Multicenter PC Trial/ (DAPIT) | 1g vitamin C and 400IU of Vitamin E or placebo | 762 diabetic pregnant women (8 - 22 weeks) | No reduction in the risk of pre-eclampsia in women with type 1 diabetes | Not Reported |
| [35] | Multicenter PC Trial | 1g vitamin C and 400IU of Vitamin E or placebo daily | 1877 women from two countries (14 - 22 weeks pregnancy) | No reduction in the risk of pre-eclampsia, intrauterine growth restriction, or other serious outcomes in their infants. | Not Reported |
| [36] | Randomized PC Trial | 1g vitamin C and 400IU of Vitamin E or placebo | 2410 Women (14 - 22 weeks pregnancy) | Does not prevent pre-eclampsia in women at risk | Increase rate of low birth-weight babies |
| [37] | Multicenter PC Trial | 1g vitamin C and 400IU of Vitamin E or placebo | 10,154 Women (9 - 16 weeks pregnancy) | No reduction in the rate of adverse maternal or perinatal outcomes | Not Reported |
| [38] | Randomized DB PC Trial | 1g vitamin C and 400IU Vitamin E or placebo | 739 Women (12 - 19 weeks pregnancy) | No benefits in reducing the rate of pre-eclampsia among patients with chronic hypertension | Not Reported |