Ref.

Study Type/Acronym

Intervention

Population/Sample Size

Results/Benefits

Adverse Effects

[21]

Randomized PC Trial/ (BLASP)

75 mg controlled-release Aspirin

3647 women (12 - 32 week pregnancy)

Do not support the routine use of low-dose aspirin for prevention of pre-eclampsia or its complications.

Not Reported

[20]

Randomized DB PC Trial

100 mg low-dose Aspirin per day

152 women (>12 week pregnancy)

Showed no statistically significant effect of aspirin in preventing pre-eclampsia

Not Reported

[22]

Randomized DB PC Trial

100 mg low-dose Aspirin per day

487 Women

No statistical difference between low-dose aspirin and placebo groups

Not Reported

[28]

Randomized Trial

100 mg low-dose Aspirin per day

40 women (<14 week pregnancy)

Limited data show some support (31.3% vs 36.8%) for early treatment with Aspirin in pregnant women

Not Reported

[29]

RCT

60 mg Aspirin per day

3135 nulliparous women (13 - 26 week pregnancy)

Low-dose aspirin decreases the incidence of pre-eclampsia in nulliparous women; 4.6% in the aspirin group and 6.3% in the placebo group (RR, 0.7; 95% CI, 0.6 to 1.0; P = 0.05)

Increases the risk of abruption placentae

[23]

Randomized DB PC Trial

100 mg low-dose Aspirin per day

3294 women (14 - 20 week pregnancy)

Does not reduce the incidence of pre-eclampsia in nulliparous women

increase in bleeding complications

[24]

RCT

150 mg low-dose Aspirin per day

560 Women (22 - 24 week pregnancy)

No significant differences between the aspirin and placebo groups

Not Reported

[25]

Randomized DB PC Trial

60 mg Aspirin per day

2503 women (13 - 26 week pregnancy)

Low-dose aspirin did not reduce the incidence of pre-eclampsia significantly or improve perinatal outcomes in pregnant women.

Not Reported

[11]

SR

Antiplatelet Agents (low-dose aspirin)

59 trials with 37,560 women

Antiplatelet Agents, largely low-dose aspirin reduce the risk of pre-eclampsia by 17% (RR 0.83, 95% CI 0.77 to 0.89)

Not Reported