Ref. | Study Type/Acronym | Intervention | Population/Sample Size | Results/Benefits | Adverse Effects |
[21] | Randomized PC Trial/ (BLASP) | 75 mg controlled-release Aspirin | 3647 women (12 - 32 week pregnancy) | Do not support the routine use of low-dose aspirin for prevention of pre-eclampsia or its complications. | Not Reported |
[20] | Randomized DB PC Trial | 100 mg low-dose Aspirin per day | 152 women (>12 week pregnancy) | Showed no statistically significant effect of aspirin in preventing pre-eclampsia | Not Reported |
[22] | Randomized DB PC Trial | 100 mg low-dose Aspirin per day | 487 Women | No statistical difference between low-dose aspirin and placebo groups | Not Reported |
[28] | Randomized Trial | 100 mg low-dose Aspirin per day | 40 women (<14 week pregnancy) | Limited data show some support (31.3% vs 36.8%) for early treatment with Aspirin in pregnant women | Not Reported |
[29] | RCT | 60 mg Aspirin per day | 3135 nulliparous women (13 - 26 week pregnancy) | Low-dose aspirin decreases the incidence of pre-eclampsia in nulliparous women; 4.6% in the aspirin group and 6.3% in the placebo group (RR, 0.7; 95% CI, 0.6 to 1.0; P = 0.05) | Increases the risk of abruption placentae |
[23] | Randomized DB PC Trial | 100 mg low-dose Aspirin per day | 3294 women (14 - 20 week pregnancy) | Does not reduce the incidence of pre-eclampsia in nulliparous women | increase in bleeding complications |
[24] | RCT | 150 mg low-dose Aspirin per day | 560 Women (22 - 24 week pregnancy) | No significant differences between the aspirin and placebo groups | Not Reported |
[25] | Randomized DB PC Trial | 60 mg Aspirin per day | 2503 women (13 - 26 week pregnancy) | Low-dose aspirin did not reduce the incidence of pre-eclampsia significantly or improve perinatal outcomes in pregnant women. | Not Reported |
[11] | SR | Antiplatelet Agents (low-dose aspirin) | 59 trials with 37,560 women | Antiplatelet Agents, largely low-dose aspirin reduce the risk of pre-eclampsia by 17% (RR 0.83, 95% CI 0.77 to 0.89) | Not Reported |