Ref. | Study Type | Intervention | Population/Sample Size | Results/Benefits | Adverse Effects |
[12] | Unblinded Multicenter Trial | Nimodipine (60mg/4h orally) and IV MgSO4 of 2g/h and 1g/h | 1650 women with severe pre-eclampsia | MgSo4 is more effective and has lower mortality rate than Nimodipine in women with severe pre-eclampsia | Increases the risk of PPH and respiratory difficulty |
[17] | Multicenter RCT | MgSo4 Versus Diazepam Versus Phenytoin | 1680 women with eclampsia from 9 countries | MgSo4 has 52% (95% CI) and 67% (95% CI) lower risk of recurrent convulsions than diazepam and phenytoin respectively | Not Reported |
[18] | Prospective Trial | 4g IV MgSO4 followed by i.m. injections or IV 0.6g/h | 630 women with eclampsia | Both interventions are equally effective in the prevention of convulsion recurrence and maternal deaths | Not Reported |
[16] | RCT | IV magnesium sulphate (4g) versus Placebo | 685 Women with Severe pre-eclampsia | IV MgSo4 is effective in reducing the incidence of severe pre-eclampsia | Not Reported |
[26] | RCT | IV MgSo4 (6g), followed by 2g/h | 222 Women with mild pre-eclampsia | No major impact on disease progression. Does not seem to increase rates of cesarean delivery, infectious morbidity, obstetric hemorrhage. | Not Reported |
[27] | SR | MgSo4 with different dose | 6 RCTs with 866 women | Strong evidence in favour of MgSo4. Lack of clarity for best dose size/route | Not Reported |
[13] | SR | MgSo4 Compared With Lytic Cocktail | 3 small trials involving 397 women | MgSo4 is more effective in reducing MM and serious maternal morbidity than Lytic cocktail. | Recurrence of seizures. |
[14] | SR | MgSO4 and Other Anticonvulsants | 15 RCTs with more than 12000 women | MgSo4 reduce the risk of eclampsia by 50% (95% CI) and is more effective than phenytoin, diazepam or nimodipine | Flushing |