Treatment

Agent Type

Dose and

Frequency

Infusion Time

Infusion Rate

Chemotherapy

Irinotecan

[32]

125 mg/m² given weekly. This cycle may be repeated.

1.5 hr

$v_{C1}=57.947\text{mg}/\text{L}\cdot \text{day}$

Chemotherapy

(Hypothetical)

125 mg/m² given weekly. This chemotherapy agent was assumed to have the same cytotoxic properties on the tumor and immune cells as Irinotecan. It was assumed that tumor cells never develop resistance to this drug.

This cycle may be repeated.

1.5 hr

$v_{C2}=57.947\text{mg}/\text{L}\cdot \text{day}$

Monoclonal antibody

Cetuximab

[32]

Loading dose (LD): 400 mg/m² (a one-time injection before giving the maintenance doses)

Maintenance dose (MD): 250 mg/m² (given weekly ? start one week after giving LD and rest 2 weeks every 4 weeks).

This cycle may be repeated.

LD: 2 hr

MD: 1 hr

$\text{LD}:v_A=139.072\text{mg}/\text{L}\cdot \text{day}$

$\text{MD}:v_A=173.840\text{mg}/\text{L}\cdot \text{day}$

Note: the same infusion term v_A is used for cetuximab and for panitumumab, but their v_A values are different.