Parameter | Description | % Change in Tumor Size | |

Parameter decreased by 5% | Parameter increased by 5% | ||

${a}_{w}$ | Growth rate of wild-type tumor cells. | −0.0001000% | 0.0000905% |

${T}_{K}$ | Carrying capacity of wild-type and mutant tumor cells combined in the absence of tumor angiogenesis. | −0.0022626% | 0.0022626% |

$\alpha $ | Rate of circulating lymphocyte production. | 0.0000786% | −0.0000782% |

${p}_{1}$ | Maximum rate of production of TGF-β by hypoxic tumor cells. | −1.8985642% | 1.7851783% |

${b}_{1}$ | Critical tumor size at which the angiogenic switch occurs. | 0.0000014% | −0.0000014% |

${S}_{1}$ | Concentration of TGF-β necessary to reduce the CD8+ T cell killing rate of tumor cells by half. | 0.0000000% | −0.0000000% |

w | Rate of Treg cell production. | −0.0000055% | 0.0000054% |

${b}_{K}$ | Proliferation rate of angiogenic endothelial cells. | −2.0499774% | 1.9076866% |

${K}_{max}$ | Rate at which TGF-β stimulates tumor growth. | −3.7233483% | 3.6382439% |

e | Rate of NK synthesis. | 0.0000937% | −0.0000938% |

${r}_{1}$ | Rate of activation of CD8+ T cells due to NK cell-lysed tumor cell debris. | 0.0000003% | −0.0000003% |

${p}_{R}$ | Rate of IL-2-induced Treg cell proliferation. | −0.0000097% | 0.0000097% |

d | Immune strength coefficient. | 0.0000004% | −0.0000004% |

l | Immune system strength scaling coefficient. | −0.0000097% | 0.0000042% |

s | Value describing how quickly CD8+ T cells respond to the presence of a tumor. | −0.0000004% | 0.0000004% |

${\lambda}_{Mo}$ | Differentiation rate of monocytes to M1 macrophages and to M2 macrophages. | −0.0000004% | 0.0000004% |

${\lambda}_{{M}_{2}}$ | Maximal rate at which M1 macrophages are activated to become M2 macrophages. | −0.0000000% | 0.0000000% |

${M}_{0}$ | Source term of monocytes. | −0.0000004% | 0.0000004% |

${T}_{0}$ | Source term of naïve helper T cells. | −0.0000721% | 0.0000694% |

${\lambda}_{{T}_{2}}$ | Production rate of Th2 cells. | −0.0000001% | 0.0000001% |

${\lambda}_{{I}_{4}{M}_{2}}$ | Production rate of IL-4 by M2 macrophages. | −0.0000000% | 0.0000000% |

${\lambda}_{{I}_{10}{M}_{2}}$ | Production rate of IL-10 by M2 macrophages. | −0.0000003% | 0.0000002% |

${\lambda}_{{I}_{10}{T}_{2}}$ | Production rate of IL-10 by Th2 cells. | −0.0000001% | 0.0000001% |