λ T α T 1

Production rate of TNF-alpha by Th1 cells

13.91

IU cell−1 day−1

Est. from [31]

λ I 10 T 2

Production rate of IL-10 by Th2 cells

0.02

IU cell−1 day−1

Est. from [31]

λ I 12 T 1

Production rate of IL-12 by Th1 cells

0.13

IU cell−1 day−1

Est. from [31]

d M 1

Death rate of M1 macrophages

0.02

day−1

[31]

d M 2

Death rate of M2 macrophages

0.008

day−1

[31]

d T 1

Death rate of Th1 cells

1.97 × 10 1

day−1

[31]

d T 2

Death rate of Th2 cells

1.97 × 10 1

day−1

[31]

d I γ

Degradation rate of IFN-γ

2.16

day−1

[31]

d T α

Degradation rate of TNF-α

55.45

day−1

[31]

d I 1 β

Degradation rate of IL-1β

6.65

day−1

[31]

d I 4

Degradation rate of IL-4

50

day−1

[31]

d I 10

Degradation rate of Il-10

8.32

day−1

[31]

d I 12

Degradation rate of IL-12

1.38

day−1

[31]

d I α

Degradation rate of IFN-α

2.16

day−1

Est. from [31]

M 0

Constant source of monocytes

5 × 10 10

cells L−1

[31]

T 0

Constant source of naïve T cells

2 × 10 10

cells L−1

[31]

K T 1

Th1 cell saturation

1 × 10 10

cells L−1

[31]

K I γ

IFN-γ saturation

2.6 × 10 6

IU L−1

[31]

K I 2

IL-2 saturation

8 × 10 6

IU L−1

[31]

K I 4

IL-4 saturation

2.6 × 10 6

IU L−1

[31]

K I 10

IL-10 saturation

3 × 10 4

IU L−1

Est. from [31]

K I 12

IL-12 saturation

1.95 × 10 8

IU L−1

[31]

K M 1

M1 saturation

5 × 10 10

cells L−1

[31]

K M 2

M2 saturation

1 × 10 11

cells L−1

[31]

K I 1 β

IL-1β saturation

1.3 × 10 5

IU L−1

[31]

K I α

IFN-α saturation

2.6 × 10 6

IU L−1

Est. from [31]

K T α

TNF-α saturation

1.3 × 10 7

IU L−1

[31]

K T G F β

TGF-beta saturation

2600

IU L−1

Est. from [31]

g T G F β

Concentration of TGF-β for half-maximal activation of Tregs

7 × 10 4

IU L−1

Est.