p I 2

Rate of CD8+ T cell activation induced by IL-2

2.4036

day−1

[32]

g I 2

Concentration of IL-2 necessary for half-maximal CD8+ T cell activation

2.5036 × 10 3

IU L−1

[32]

u

Rate of inhibition of surplus CD8+ T cells induced by Treg cells in the presence of IL-2

2.3085 × 10 13

L2 cell−2 day−1

[49]

κ

Concentration of IL-2 required to halve the immunosuppressive effect of Treg cells on CD8+ T cells

2.5036 × 10 3

IU L−1

[49]

j

Rate of activation of CD8+ T cells due to CD8+ T cell-lysed tumor cell debris

1.245 × 10 4

day−1

[32]

k

Tumor size required for half-maximal CD8+ T cell activation by CD8+ T cell-lysed tumor cell debris

2.019 × 10 7

cells

[32]

K L

Rate of CD8+ T cell depletion from chemotherapy toxicity

4.524 × 10 1

day−1

[32]

δ L

Coefficient of chemotherapy toxicity on CD8+ T cells

2 × 10 1

L mg−1

[32]

β

Rate of circulating lymphocyte turnover

6.3 × 10 3

day−1

[32]

α

Rate of circulating lymphocyte production

( 3 × 10 9 ) β

cells L−1 day−1

[32]

K C

Rate of lymphocyte depletion from chemotherapy toxicity

5.7 × 10 1

day−1

[32]

δ C

Coefficient of chemotherapy toxicity on circulating lymphocytes

2 × 10 1

L mg−1

[32]

μ I 2

Rate of excretion and elimination of IL-2

11.7427

day−1

[32]

ω

Rate of IL-2 production from CD8+ T cells

7.88 × 10 2

IU cell−1 day−1

[32]

ϕ

Rate of IL-2 production from circulating CD4+ and naive CD8+ T cells

1.788 × 10 7

IU cell−1 day−1

[32]

ζ

Concentration of IL-2 for half-maximal CD8+ T cell IL-2 production

2.5036 × 10 3

IU L−1

[32]

γ 1

The rate of excretion and elimination of irinotecan

4.077 × 10 1

day−1

[32]

η

Rate of cetuximab and panitumumab turnover and excretion

1.386 × 10 1

for cetuximab

9.242 × 10 2

for panitumumab

day−1

[32]