AA patterns

Disease association

Target organelle or antigen

Speckled

Homogeneous/difuse

Peripheral/rim

Centromere

Mitotic apparatus

Nucleolar

Cytoplasmic

SLE, SSc, SjS, MCTD, SCLE, NLS

SLE, DIL, SSc, AH

SLE, APS, AH

RP, IcSSc,

SLE, SjS

dcSSc, SLE, PM, RP

PM, DM, SLE, SjS, PBC, SSc

Sm, RNP, SS-A/Ro, SS-B/La, PCNA, RNAP II/III, Topo I

dsDNA, chromatin, Histone

Nuclear envelop

CENP-A,B,C

NuMA1, NuMA2, (HsEg5)

PM/Scl, fibrillarin (U3-RNP), RNAPI/III, NOR-90(hUBF)

Ribosomes, mitochondria, Golgi complex, endosomes, GW bodies, SRP, Io-1