| Patients, age | Signs of onset | New clinical signs | New paraclinical signs | Retained diagnosis | Duration of follow-up |
| P1, 54 years | Chronic symmetrical peripheral polyarthritis without deformity, without extra-articular signs Biological inflammatory syndrome X-ray of hands, wrists and feet: normal Immunology: negative (rheumatoid factors, ACPA, ANA, anti-ENA, anti-DNAn) | 0 | ACPA (+) at 7.7 IU/mL | RA | 3 years |
| P2, 67 years | 0 | Ultrasound of the hands: bilateral synovitis of the MCP and PIP; erosion of the head of the right 2nd metacarpal | RA | 4 years | |
| P3, 28 years | Oculo-buccal dry syndrome | Schirmer’s test: positive Accessory salivary gland biopsy: grade III sialadenitis | Sjögren’s syndrome | 4 years | |
| P4, 43 years | Dry mouth | Accessory salivary gland biopsy: sialadenitis grade IV | Sjögren’s syndrome | 5 years | |
| P5, 33 years | 0 | ACPA: (−) ANA: 1/160 | SLE | 5 years | |
| P6, 32 years | Skin sclerosis (Rodnan score 21/51) PIP shrinkage Hypochromic macules in speckles | No further explorations | Systemic scleroderma | 5 years | |
| P7, 19 years | Skin sclerosis (Rodnan score 18/51) | ANA: 1/100 Anti-SSA: 8 IU/mL ACPA: (−) X-ray: periarticular calcifications in hands and elbows | Systemic scleroderma | 8 years |