Category

Term

Count

%*

P Value^t

Genes

Up-regulated

KEGG_

PATHWAY

hsa04060:Cytokine-cytokine receptor interaction

28

7.272727273

5.42E−09

CXCL1, TNFRSF21, TNFRSF12A, CSF1, CXCL2, TNFSF15, CCL8, TNFRSF8, CX3CL1, TNFRSF11B, TNFRSF1B, IL23A, CCL20, TNFRSF18, CSF3R, IL1B, CSF2RB, PRL, IL1A, IL2RA, IL8, OSM, INHBA, IFNAR2, RELT, TNFRSF10D, CXCL16, PDGFRB

KEGG_

PATHWAY

hsa05200:Pathways in cancer

24

6.233766234

6.57E−05

FGF18, PLD1, EPAS1, PTGS2, IL8, NFKBIA, NFKB2, BIRC3, RALGDS, MMP1, SHH, IGF1R, RASSF5, CBLB, CDKN1A, CDKN2B, LAMC3, ETS1, ITGAV, SLC2A1, CSF3R, PDGFRB, RUNX1, FGF2

KEGG_

PATHWAY

hsa04621:NOD-like receptor signaling pathway

10

2.597402597

6.83E−05

CXCL1, NOD2, IL8, CXCL2, CCL8, NFKBIA, IL1B, RIPK2, TNFAIP3, BIRC3

KEGG_

PATHWAY

hsa04640:Hematopoietic cell lineage

10

2.597402597

7.80E−04

IL2RA, GP1BB, ITGA5, CSF1, IL1B, CSF3R, ITGB3, IL1A, HLA-DRA, CD7

KEGG_

PATHWAY

hsa04610:Complement and coagulation cascades

8

2.077922078

0.003833629

PLAT, C5AR1, CFB, F3, TFPI, PLAU, F2R, PLAUR

KEGG_

PATHWAY

hsa04666:Fc gamma R-mediated phagocytosis

8

2.077922078

0.020908628

PLD1, MYO10, FCGR2C, CFL2, SPHK1, ASAP1, FCGR2A, FCGR3A

KEGG_

PATHWAY

hsa04810:Regulation of actin cytoskeleton

13

3.376623377

0.021870623

GNA13, FGF18, SSH1, MRAS, GNA12, ITGB3, ITGA5, ITGAV, CFL2, ITGB6, PDGFRB, FGF2, F2R

KEGG_

PATHWAY

hsa04630:Jak-STAT signaling pathway

10

2.597402597

0.037676726

OSM, IFNAR2, CBLB, IL23A, IL2RA, SOCS3, PIM1, CSF2RB, CSF3R, PRL

KEGG_

PATHWAY

hsa04920:Adipocytokine signaling pathway

6

1.558441558

0.045904686

IRS2, TNFRSF1B, NFKBIE, SOCS3, SLC2A1, NFKBIA

KEGG_

PATHWAY

hsa04010:MAPK signaling pathway

14

3.636363636

0.046369117

FGF18, MRAS, RELB, GNA12, NFKB2, DUSP4, RASGRP1, GADD45G, MAP3K8, IL1B, PDGFRB, NFATC2, FGF2, IL1A

Down-regulated

KEGG_

PATHWAY

hsa00280:Valine, leucine and isoleucine degradation

14

2.337228715

5.24E−10

ALDH6A1, ACADM, BCAT2, EHHADH, BCKDHB, ACAT1, ALDH3A2, HIBADH, DBT, ALDH7A1, IVD, MCCC1, OXCT1, PCCB

KEGG_

PATHWAY

hsa00640:Propanoate metabolism

11

1.83639399

3.10E−08

ALDH6A1, LDHB, ALDH7A1, ACADM, SUCLG2, EHHADH, ACACA, ACSS2, ACAT1, PCCB, ALDH3A2

KEGG_

PATHWAY

hsa00071:Fatty acid

metabolism

9

1.502504174

3.05E−05

CPT1C, ALDH7A1, ACADM, EHHADH, ADH5, ADH5P4, ACAT1, ALDH3A2, DCI, CPT1A

KEGG_

PATHWAY

hsa00310:Lysine degradation

8

1.335559265

4.35E−04

SETDB1, ALDH7A1, EHHADH, SETMAR, TMLHE, ACAT1, ALDH3A2, SUV420H1

KEGG_

PATHWAY

hsa00620:Pyruvate metabolism

7

1.168614357

0.001551163

LDHB, ALDH7A1, ACACA, DLAT, ACSS2, ACAT1, ALDH3A2

KEGG_

PATHWAY

hsa00010:Glycolysis/ Gluconeogenesis

8

1.335559265

0.002853392

LDHB, GALM, ALDH7A1, ADH5, DLAT, PFKM, ACSS2, ADH5P4, ALDH3A2

KEGG_

PATHWAY

hsa00650:Butanoate metabolism

6

1.001669449

0.003677294

ALDH7A1, OXCT1, EHHADH, ACAT1, BDH1, ALDH3A2

KEGG_

PATHWAY

hsa00072:Synthesis and degradation of

ketone bodies

3

0.500834725

0.031809524

OXCT1, ACAT1, BDH1

KEGG_

PATHWAY

hsa00410:beta-Alanine metabolism

4

0.667779633

0.031983898

ALDH7A1, ACADM, EHHADH, ALDH3A2

KEGG_

PATHWAY

hsa00380:Tryptophan metabolism

5

0.834724541

0.038178672

ALDH7A1, CYP1B1, EHHADH, ACAT1, ALDH3A2

KEGG_

PATHWAY

hsa00980:Metabolism of xenobiotics by

cytochrome P450

6

1.001669449

0.0399123

GSTA4, GSTM4, CYP1B1, GSTK1, ADH5, ADH5P4, GSTM5