Isolate Number | Resistance Pattern | PZA susceptibility testing | DNA Sequencing of pncA gene | |||||
MGIT | HRM (F) | Type of change | Codon number¤ | Nucleotide change | Amino acid change | |||
From | To | |||||||
1 | RIF, INH,STR, EMB, ETH, KAN, OFX | R | S | Insertion | 173 | - | C | Glu173Frameshift ** |
2 | INH | S | R (F3) | No change | - | - | - | - |
3 | RIF, INH | R | S | Substitution | 59 | A | G | Ser59Pro ** |
4 | RIF, INH, OFX | R | S | Substitution | 14 | A | G | Cys14Arg * |
5 | IHN, STR | R | S | Substitution | 51 | G | C | His51Asp ** |
6 | INH, STR, EMB | R | R (F1) | No change | - | - | - | - |
7 | RIF, INH | R | R (F1) | Substitution | 139 | A | C | Va139Gly * |
8 | INH,STR, ETH | S | S | No change | - | - | - | - |
9 | RIF, INH | R | S | Substitution | 14 | G | C | Cys14Trp ** |
10 | RIF, INH | S | R (F1) | No change | - | - | - | - |
11 | RIF, INH | R | R (F2, F3) | Substitution | 14 | G | C | Cys14Trp ** |
12 | INH | R | R (F3) | No change | - | - | - | - |
13 | RIF, INH | S | S | No change | - | - | - | - |
14 | RIF, INH | R | S | Substitution | 134 | G | T | Ala134Asp ** |
15 | RIF, INH | S | R (F3) | Substitution | 139 | A | C | Val139Gly * |
16 | RIF, INH, ETH | R | R (F3) | Substitution | 12 | T | C | Asp12Gly * |
17 | INH | S | R (F3) | Substitution | 34 | A | C | Tyr34Asp ** |
18 | RIF, INH, EMB, OFX | R | R (F1, F2, F3) | No change | - | - | - | - |
19 | RIF, INH | R | R (F1, F2, F3) | No change | - | - | - | - |