S.No

Time in

days

Physical

changes

Percentage

drug content (mg)

Percentage of in vitro

drug release

1.

0

----

84.68 ± 1.09

82.12 ± 3.24

2.

15

No change

84.68 ± 1.12

82.10 ± 2.48

3.

30

No change

84.67 ± 1.26

82.09 ± 2.23

4.

45

No change

84.67 ± 1.78

82.09 ± 1.52

5

60

No change

84.66 ± 2.93

82.08 ± 1.36

6

75

No change

84.65 ± 2.93

82.08 ± 3.44

7

90

No change

84.65 ± 2.93

82.06 ± 1.84