| Gene ID | Gene Name | #6NIC1.V1.1-1 No UV | v#6NIC1.V1.1-1 + UV + #6NIC1.V1.1-1 | Function in the skin | Results | ||
| FC | %C | ||||||
| DHRS9 | Dehydrogenase/ Reductase 9 | 17.98 | 1698% | 18.38 | 1738% | Oxidative Stress Response | In keratinocytes, DHRS9 is known to be involved in the process of conversion of retinol into retinoic acid [14] [15] . Its activation is generally considered to be a sign of production of retinoic acid [15] . Its expression might be affected by retinoic acid levels and UVB exposure. |
| LRAT | Lecithin Retinol Acyltransferase | 10.65 | 965% | 6.74 | 574% | Oxidative Stress Response | Responsible for retinoid absorption and storage, its downregulation can lead to depletion of vitamin A in the skin cells which in turn would cause oxidative stress [16] . Acute UVB exposure can be responsible for lower levels of LRAT [17] . |
| ANXA1 | Annexin A1 | 2.54 | 154% | 4.98 | 398% | Oxidative Stress Response, Inflammation | Marker of collagen production increase, ANXA1 is also known to be a powerful anti-inflammatory within human keratinocytes, inhibiting pro-inflammatory responses [18] [19] . |
| CSF2 | Colony Stimulating Factor 2 | 7.91 | 691% | 11.64 | 1064% | Inflammation | Involved in multiple biological functions, CSF2 is known for its activity of [20] [21] : - Regulating extracellular matrix proteins expression - Inducing keratinocyte proliferation and differentiation in order to facilitate early wound healing - Stimulating the epidermal melanocytes proliferation and differentiation in response to UVB exposure |
| IL1A | Interleukin 1 alpha | 3.31 | 231% | 3.25 | 225% | Inflammation | Interleukin-1 alpha is an epidermal resident cytokine acting as a regulator of the skin structure and functions [22] [23] . When upregulated it is known to manage dermal collagen turnover as well as stimulating the production of hyaluronic acid [23] . It potentially can inhibit the tyrosinase activity leading to a reduction of melanogenesis [23] . |