ENVIRONMENTAL STRESS PANEL GENE LIST

DNA REPAIR

OXIDATIVE STRESS RESPONSE

» ATM: ataxia-telangiectasia mutated

» AHR: aryl hydrocarbon receptor

» EGR1: early growth response 1

» AIFM2: apoptosis inducing factor mitochondria associated 2

» GADD45A: growth arrest and DNA damage inducible alpha

» ANXA1: annexin a1

» H2AFX: h2A.X Variant histone

» CAT: catalase

» MGMT: o-6-methylguanine-DNA methyltransferase

» CYP1A1: cytochrome p450 family 1 subfamily a member 1

» PARP1: PARP enzyme (NAD)

» CYP1B1: cytochrome p450 family 1 subfamily b member 1

» PCNA: proliferating cell nuclear antigen

» DHRS9: dehydrogenase/reductase 9

» POLB: DNA polymerase beta

» GPX1: glutathione peroxidase 1

» TDG: thymine DNA glycosylase

» GPX3: glutathione peroxidase 3

» XRCC1: x-ray repair cross complementing 1

» HIF1a: hypoxia inducible factor 1 subunit alpha

» XRCC2: x-ray repair cross complementing 2

» HMOX1: heme oxygenase 1

» XRCC4: x-ray repair cross complementing 4

» HSP90AA1: heat shock protein 90 kDa alpha (cytosolic), class a member 1

EPIGENETICS

» HSPD1: heat shock 60 kDa protein 1 (chaperonin)

» DNMT1: DNA methyltransferase 1

» KEAP1: kelch like ECH associated protein 1

» DNMT3A: DNA methyltransferase 3 alpha

» LRAT: lecithin retinol acyltransferase

» DNMT3B: DNA methyltransferase 3 beta

» MAPK14: mitogen-activated protein kinase 14 (p38)

» FTO: FTO alpha-ketoglutarate dependent dioxygenase

» MT1G: metallothionein 1G

» HDAC1: histone deacetylase 1

» NAMPT: nicotinamide phosphoribosyltransferase

» HDAC3: histone deacetylase 3

» NFE2L2: nuclear factor, erythroid 2 like 2 (NRF2)

» HDAC8: histone deacetylase 8

» NOX4: NADPH oxidase 4

» METTL3: methyltransferase like 3

» NQO1: NAD(P)H quinone dehydrogenase 1

» TET1: tet methylcytosine dioxygenase 1

» PDSS1: decaprenyl diphosphate synthase subunit 1

» TET2: tet methylcytosine dioxygenase 2

» PRDX2: peroxiredoxin 2

» TIMELESS: timeless circadian regulator

» PRDX3: peroxiredoxin 3

INFLAMMATION

» PRDX6: peroxiredoxin 6

» AHR: aryl hydrocarbon receptor

» SOD1: superoxide dismutase 1, soluble

» ANXA1: annexin a1

» TXNRD1: thioredoxin reductase 1

» CASP1: caspase 1

» UCP1: uncoupling protein 1

» CCL2: C-C motif chemokine ligand 2

» UCP2: uncoupling protein 2

» CSF2: colony stimulating factor 2

» UCP3: uncoupling protein 3

» CXCL8: C-X-C motif chemokine ligand 8 (IL8)

SKIN AGING/EXTRACELLULAR MATRIX MODULATION

» HSPD1: heat shock 60 kDa protein 1 (chaperonin)

» CASP14: caspase 14

» IFNG: interferon gamma

» CDKN2A: cyclin dependent kinase inhibitor 2A (p16)

» IL18: interleukin 18

» COL1A1: collagen type i alpha 1 chain

» IL1A: interleukin 1 alpha

» ELN: elastin

» IL1B: interleukin 1 beta

» FBN1: fibrillin 1

» IL24: interleukin 24

» FLG: filaggrin

» IL33: interleukin 33

» HAS2: hyaluronan synthase 2

» IL6: interleukin 6

» LOXL1: lysyl oxidase like 1

» NFKB1: nuclear factor kappa b subunit 1 (p50)

» MMP1: matrix metallopeptidase 1

» NLRP3: NLR family pyrin domain containing 3

» MMP9: matrix metallopeptidase 9

» PTGS2: prostaglandin-endoperoxide synthase 2 (COX-2)

» NAMPT: nicotinamide phosphoribosyltransferase

» PYCARD: PYD and CARD domain containing

» PANK4: pantothenate kinase 4

» TLR3: toll like receptor 3

» SIRT1: sirtuin 1

» TLR5: toll like receptor 5

» TIMP1: TIMP metallopeptidase inhibitor 1

» TNF: tumor necrosis factor

SURVIVAL/APOPTOSIS

MITOCHONDRIAL FUNCTION & BIOGENESIS

» BAK1: bCL2-antagonist/killer 1

» AIFM2: apoptosis inducing factor mitochondria associated 2

» BCL2: bCL2 apoptosis regulator

» ATP5F1B: ATP synthase f1 subunit beta

» EGR1: early growth response 1

» COX10: cytochrome c oxidase assembly factor heme

» FOXO1: forkhead box o1

a: farnesyltransferase COX10

» FOXO3: forkhead box o3

» COX4I1: cytochrome c oxidase subunit 4I1

» MAP1LC3A: microtubule associated protein 1 light chain 3 alpha

» COX5B: cytochrome c oxidase subunit 5B

» MAPK1: mitogen-activated protein kinase 1

» COX6B1: cytochrome c oxidase subunit 6B1

» MKI67: marker of proliferation ki-67

» COX7A1: cytochrome c oxidase subunit 7A1

» SQSTM1: sequestosome 1 (p62)

» CYC1: cytochrome c1

» TP53: tumor protein p53

» NDUFA11: NADH:ubiquinone oxidoreductase subunit a11

» TP73: tumor protein p73

» POLG1: DNA polymerase gamma, catalytic subunit

WOUND HEALING

» PPARGC1A: PPARG coactivator 1 alpha

» HIF1a: hypoxia inducible factor 1 subunit alpha

» SDHB: succinate dehydrogenase complex iron sulfur subunit b

» HSP90AA1: heat shock protein 90 kDa alpha (cytosolic), class a member 1

» SOD2: superoxide dismutase 2, mitochondrial

» HSPD1: heat shock 60 kDa protein 1 (chaperonin)

» TFAM: transcription factor a, mitochondrial

» UCP1: uncoupling protein 1

» UCP2: uncoupling protein 2

» UCP3: uncoupling protein 3