Evolution of the severity of

wrinkles and fine lines

D1

D15

D30

D45

D75

D90

0—none

N

2

2

3

4

8

8

%

5%

6%

8%

11%

21%

21%

1—not very marked

N

12

10

20

24

26

26

%

32%

28%

54%

65%

68%

68%

2—marked

N

16

20

12

8

4

4

%

43%

56%

32%

22%

11%

11%

3—very marked

N

7

4

2

1

0

0

%

19%

11%

5%

3%

-

-

N

37

36

37

37

37

38

Mean

1.8

1.7

1.4

1.2

0.9

0.9

Sd

0.8

0.7

0.7

0.6

0.5

0.6

Min

0

0

0

0

0

0

Median

2

2

1

1

1

1

Max

3

3

3

3

2

2

% of improvement vs D1

−2%

−23%

−34%

−46%

−50%

Comparison/D1 versus D15

NS. p = 0.5541

Comparison/D1 versus D30**

S. p = 0.0042

Comparison/D1 versus D45***

S. p = 0.0005

Comparison/D1 versus D75***

S. p < 0.0001

Comparison/D1 versus D90***

S. p < 0.0001

Comparison/D15 versus D30**

S. p = 0.0010

Comparison/D15 versus D45***

S. p < 0.0001

Comparison/D15 versus D75***

S. p < 0.0001

Comparison/D75 versus D90

NS. p = 0.3613