Compound | Percentage of survivala (IC50, μM of selected compounds)b | ||||||
Huh7-D12 | Caco 2 | MDA-MB231 | HCT 116 | PC3 | NCI-H727 | HaCat | |
5a | 113 | 79 | 64 | 73 | 81 | 116 | 87 |
5b | 126 | 83 | 129 | 77 | 90 | 75 | 97 |
5c | 137 | 80 | 104 | 88 | 99 | 95 | 108 |
5d | 119 | 86 | 96 | 87 | 91 | 121 | 90 |
5e | 79 (33) | 64 (21) | 54 (39) | 95 (15) | 79 (44) | 70 (>25) | 92 (38) |
5f | 118 | 81 | 124 | 93 | 123 | 124 | 102 |
5g | 143 | 92 | 127 | 110 | 98 | 95 | 114 |
5h | 226 | 86 | 96 | 95 | 133 | 198 | 85 |
Roscovitine | 21 (15) | 3 (15) | 21 (12) | 10 (9) | 24 (13) | 30 (43) | 6 (11) |
Doxorubicine | 63 (0.03) | 43 (0.03) | 82 (0.01) | 22 (0.03) | 34 | 65 | 88 (0.02) |
DMSO | 100 (>25) | 100 (>25) | 100 (>25) | 100 (>25) | 100 (>25) | 100 (>25) | 100 (>25) |