Factors related to Amikacin toxicity

AG1* (n = 140)

AG2* (n = 292)

P value

Duration of Amikacin treatment (≥6 days)

31 (22)

38 (13)

0.02

High Amikacin dose **

47 (34)

102 (35)

0.8

Sepsis

18 (13)

39 (13)

1.0

Septic shock or Hypotension

29 (21)

58 (20)

0.1

Age

70 - 80 years

32 (23)

66(23)

1.0

81 - 90 years

59 (42)

130(46)

0.7

>90 years

25 (18)

47(16)

0.7

Dehydration (and nausea/vomiting)

6 (4)

12 (4)

0.6

Elevated Amikacin trough serum level

50 (36)

61 (21)

0.001

Previous exposure to aminoglycosides (recurrent therapy)***:

During one year before hospitalization

During study period recurrent course

37 (29)

12 (9.3)

75 (28)

28 (10.2)

0.9

0.9

Number of hospitalizations without fluids administration

25 (18)

58 (20)

0.7

Concomitant medications¹:

Vancomycin

NSAIDS

ACE and ARBs

Diuretics:

Furosemide

Hypertension (without diuretics, ACE\ARBs)

Antiarrhythmic (without CCB\BB):

Digoxin

Chemotherapy

8 (6)

-

58 (41)

57 (41)

46

72 (51)

8 (6)

6

1 (0.7)

13 (4.5)

2 (0.7)

118 (40)

107 (37)

92

135 (46)

23 (8)

15

0

0.7

1.0

0.4

0.5

0.8

0.4

0.6

0.8

0.3

Ears disorders per history

6 (4)

16 (6)

0.9

Obesity per history

20 (14)

46 (16)

0.6