Pharmacokinetic parameters

Group I

CurCousin^®

(4.5 mg/kg)

Group II

CurCousin^® + BioPerine^®

(2.25 + 0.27 mg/kg)

Bioavailability of Calebin A in CurCousin^® (4.5 mg/kg)

compared to

CurCousin^® + BioPerine^®

(2.25 + 0.27 mg/kg)

C_max (ng/mL)

1.3496

1.2293

97.44%

T_max (h)

2

4

K_el (h)

0.0286

0.0350

t_1/2 (h)

24.2434

19.7917

AUC_0-24 (ng∙h/mL)

19.0769

18.5891

AUC_0-∞ (ng∙h/mL)

53.3480

45.1119