Test group + dose

(human equivalent dose)

Test group + dose

(rat equivalent dose)

Sub-groups

No. of animals

Blood sampling

Time points (8)

Group I

CurCousin^® (50 mg)

CurCousin^®

(4.5 mg/kg b.w)

Group 1

3

0 min

1 h

12 h

Group 2

3

15 min

2 h

24 h

Group 3

3

30 min

4 h

-

Group II

CurCousin^® + BioPerine^®

(25 mg + 3 mg)

CurCousin^®+BioPerine^®

(2.25 mg/kg + 0.27 mg/kg b.w)

Group 1

3

0 min

1 h

12 h

Group 2

3

15 min

2 h

24 h

Group 3

3

30 min

4 h

-