| Authors | Model | Experimental Model | CBD dose & Route of administration | Cardiac & Chemical Outcomes | Other Findings (Proposed mechanism of action) |
| 1) Durst et al. 2007 | Induction of myocardial infarction and reperfusion in rats | Male Sprague Dawley rats were operated with LAD occlusion for 30 min and then released | In vivo: intraperitoneal CBD 5 mg/kg one hour prior to surgery and once a day for the next 7 days | Infarct size significantly reduced in the CBD group (66% reduction) Lower inflammatory response in the CBD group. | Immunomodulatory effect (IL6-lowering effects) Activation of adenosine receptors |
| 2) Feng et al. 2015 | Induction of myocardial infarction and reperfusion in rabbits | Ischemia Reperfusion Model. Through surgery, the the circumflex artery is occluded for 90 minutes. | CBD 100 µm/kg intravenously 10 minutes before occlusion and 10 minutes before reperfusion. | Significantly less Trop I in rabbits treated with CBD Significant improvement in lateral wall thickness Significant increase in coronary flow to the region of the infarct Minor zones of microvascular occlusion The smaller size of the infarct area Fewer areas of hemorrhage, fewer leukocytes, and less apoptosis | Increased adenosine, increased NO levels CBD binds to PPARÉ£ which decreases the expression of inducible ON synthase It has also been seen to decrease monocyte adhesion and transmigration (atherosclerosis) |
| 3) Castillo et al. 2021 | Induction of ischemia/ reperfusion in rats | Male Wistar rats were divided into 3 groups. Surgery to ligate the LAD and cause ischemia for 45 minutes. | Control (SHAM for I/R surgery) Group with I/R I/R group treated with CBD 5 mg/kg intraperitoneal for 10 days prior to surgery | Better hemodynamic parameters in the hearts of rats treated with CBD Significant reduction of the infarct zone Increased expression of AT2, without elevation of AT1 in rats treated with CBD Increased expression of Akt and ERK | Activation of AT2 could explain RISK activation, the latter has been found to be decreased in heart failure and I/R injury |
| 4) Walsh et al. 2010 | Induction of arrhythmias during reperfusion injury in rats | Surgery to occlude the LDA for 30 minutes and then reperfusion for 2 hours in male Sprague Dawley rats | Intravenous, 2 doses 10 and 50 µg/kg 10 minutes before occlusion and 10 minutes before reperfusion | Treatment with 50 µg/kg CBD prior to occlusion significantly reduced VT and ventricular ectopic beats. The administration of 50 µg/kg CBD prior to ischemia and prior to reperfusion decreased the size of the infarct 50 µg/kg CBD reduced platelet aggregation ex vivo | CBD decreased VT when given before ischemia, but not before reperfusion. CBD can have a PPAR gamma effect and through this effect be anti-inflammatory. GPR55 receptor antagonist. CBD improves Ca homeostasis through NCX. |
| 5) Gonca et al. 2015 | Induction of arrhythmias during reperfusion injury in male rats | Albino Wistar rats. Surgery to tie the LAD for 6 minutes and then untie for another 6 minutes. | 4 experimental groups Control CBD 50 µg/kg IV 10 minutes before occlusion DPCPX selective A1 receptor antagonist 15 minutes before occlusion CBD followed by DPCPX 10 and 15 minutes before IV occlusion | CBD alone decreased arrhythmias, VT duration time. Co-administration of both did not reduce arrhythmias. None of the drugs affected the QT. | Effect of CBD by inhibiting rectifying current K channels, which prolongs the action potential and QT interval and suppresses arrhythmias in ischemia animals. Activation of the A1 receptor through inhibition of adenosine uptake by ENT. |