Subgroup Analysis

Number of Studies Included

Results of Heterogeneity Test

Effect Model

Results of Meta-analysis

(%, 95% CI)

I2 (%)

P Value

The total patient delay rate

60 [3, 4, 11 - 68]

98.95

<0.001

Random

46.4 (44.3, 48.4)

Gender

Male

13 [3, 4, 17, 18, 24 - 26, 28, 34, 37, 52, 53, 62]

98.89

<0.001

Random

46.8 (42.4, 51.1)

Female

13 [3, 4, 17, 18, 24 - 26, 28, 34, 37, 52, 53, 62]

98.85

<0.001

Random

50.4 (45.7, 55.0)

Region

East

28 [11 - 14, 20, 21, 23, 25, 28 - 31, 34, 38, 43, 47, 50, 51, 54 - 60, 64 - 66]

96.73

<0.001

Random

42.3 (37.2, 47.4)

Central

7 [32, 33, 35, 41, 48, 49, 67]

96.54

<0.001

Random

45.6 (37.3, 53.8)

West

23 [4, 15 - 19, 22, 24, 26, 27, 36, 37, 39, 40, 42, 45, 46, 52, 53, 61 - 63, 68]

99.40

<0.001

Random

50.5 (47.4, 53.6)

Time

2018-2020

2 [4, 20]

96.53

<0.001

Random

28.3 (9.6, 46.9)

2015-2017

6 [4, 23, 31, 37, 40, 47]

93.20

<0.001

Random

49.0 (41.2, 56.8)

2012-2014

8 [23, 31, 40 - 42, 47, 50, 51]

96.70

<0.001

Random

46.4 (36.8, 56.1)

2007-2011

3 [42, 59, 61]

62.64

0.069

Random

39.7 (37.3, 42.0)

Study stage

Primary school

6 [24, 25, 28, 37, 55, 61]

76.48

0.001

Random

50.3 (37.8, 62.8)

Junior high school

7 [17, 24, 25, 28, 36, 37, 55]

63.41

0.012

Random

49.8 (44.8, 54.8)

Senior high school

7 [17, 24, 25, 28, 36, 37, 55]

92.82

<0.001

Random

40.7 (34.8, 46.6)

University

7 [17, 25, 28, 37, 53, 55, 61]

95.92

<0.001

Random

44.9 (37.3, 52.5)

Nationality

The Han

6 [4, 16, 19, 24 - 26]

94.85

<0.001

Random

50.3 (48.1, 52.5)

Others (ethnic minorities)

6 [4, 16, 19, 24 - 26]

97.29

<0.001

Random

53.9 (49.9, 57.9)

Household registration type

Local

5 [4, 15, 24 - 26]

96.92

<0.001

Random

47.2 (44.1, 50.3)

Non-local

5 [4, 15, 24 - 26]

89.82

<0.001

Random

50.5 (47.0, 54.0)

Detection method

Consultation due to symptoms

11 [4, 19, 24 - 26, 28, 37, 51, 53, 55, 62]

98.21

<0.001

Random

50.5 (45.2, 55.7)

Recommendation due to symptoms

5 [4, 24, 26, 28, 55]

89.78

<0.001

Random

51.6 (37.4, 65.9)

Referral

9 [4, 25, 26, 28, 37, 51, 53, 55, 62]

97.27

<0.001

Random

46.6 (38.3, 54.9)

Tracking

6 [4, 26, 37, 51, 53, 62]

89.81

<0.001

Random

55.6 (48.3, 63.0)

Healthy physical examination

7 [19, 24, 26, 28, 37, 51, 55]

91.77

<0.001

Random

16.2 (10.4, 22.0)

Treatment classification

Initial treatment

8 [3, 4, 17, 19, 24, 26, 34, 52]

99.61

<0.001

Random

53.1 (48.3, 57.9)

Retreatment

9 [3, 4, 17, 19, 24 - 26, 34, 52]

92.62

<0.001

Random

59.6 (51.7, 67.6)

Diagnostic results

With positive etiology

6 [17, 24 - 26, 37, 52]

98.79

<0.001

Random

55.9 (47.8, 64.0)

With negative etiology

6 [17, 24 - 26, 37, 52]

99.06

<0.001

Random

47.0 (40.9, 53.2)

Without etiological results

4 [24 - 26, 37]

76.25

0.006

Random

51.6 (35.2, 68.0)

Severe or non-severe

Severe

4 [4, 24, 26, 52]

98.15

<0.001

Random

59.4 (47.4, 71.4)

Non-severe

4 [4, 24, 26, 52]

99.61

<0.001

Random

52.9 (43.8, 61.9)