Mutation

Distribution Probability for Original Amino Acid

Distribution Probability for Mutated Amino Acid

Difference

Change

Before mutation

After mutation

Before mutation

After mutation

D ® A

0.3213

0.1543

0.0621

0.1544

–0.0747

¯

H ® A

0.0369

0.1682

0.0621

0.0515

0.1207

­

H ® A

0.0369

0.1682

0.0621

0.0386

0.1078

­

H ® A

0.0369

0.0105

0.0621

0.1544

0.0659

­

H ® A

0.0369

0.1682

0.0621

0.1544

0.2236

­

T ® A

0.0183

0.0177

0.0621

0.0515

–0.0112

¯

Y ® A

0.0341

0.0336

0.0621

0.1544

0.0918

­