Compds.

Properties

Maraviroc

1

2

3

4

5

6

7

Human Intestinal Absorption a

+

+

+

+

+

+

+

Blood Brain Barrier b

+

+

+

+

+

Renal organic cation transporter c

CYP450 1A2 inhibitor c

CYP450 2C9 inhibitor c

+

+

+

+

+

CYP450 2D6 inhibitor c

CYP450 2C19 inhibitor c

+

+

CYP450 3A4 inhibitor c

+

+

CYP450 inhibitory promiscuity

high

low

low

high

high

low

high

high

hERG inhibition I c

hERG inhibition II c

+

+

+

+

+

+

Ames test d

+

+

Carcinogenicity e

Aqueous solubility (Log S)

−3.7479

−3.8727

−2.4736

−3.9044

−3.7491

−3.3937

−4.3616

−4.1589