Study Author

Study Conclusion

Adly et al., 1992: 103 [ 13 ]

“The beneficial effects [of fluoxetine] observed in this study, combined with the relative lack of significant side effects, should encourage others to try to replicate these findings with a larger group over a longer period of observation”

Bank, 1994: 476 [ 14 ]

“These findings suggest, that fluvoxamine (vs. amitriptyline) may be an alternative drug in migraine prophylaxis, however, further studies should be performed with more subjects”

Bulut et al., 2004: 44 [ 2 ]

“In conclusion, it is suggested that venlafaxine may be considered for the prophylaxis of migraine because of its low and/or tolerable side effect properties”

NOTE: Financially supported by a pharmaceutical company producing venlafaxine

Colucci d’Amato et al., 1999: 718-719 [ 15 ]

“Even if preliminary and to be confirmed in a larger number of patients, these data seem to support the use of fluoxetine in migraine prophylaxis, especially when conventional treatments give no results or have serious side effects limiting their use”

Krymchantowski et al., 2002: 513 [ 16 ]

“We could not demonstrate superiority for the combination of amitriptyline and fluoxetine over amitriptyline alone in treating transformed migraine”

Landy et al., 1999: 31 [ 17 ]

“This present study and the previous literature on selective serotonin reuptake inhibitors for migraine prophylaxis do not support a major role for the use of this class of medication in migraine”

NOTE: Supported by a charity organization

Oguzhanoglu et al., 1999: 532 [ 18 ]

“Both drugs [amitriptyline and fluoxetine] benefited chronic tension-type headache and episodic tension-type headache although fluoxetine effects were less sustained. Again, increasing the dose of FLX [fluoxetine] might have provided better effect”

Ozyalcin et al., 2005: 144 [ 19 ]

“Venlafaxine was more effective than placebo and is safe and well tolerated as migraine prophylaxis”

NOTE: Financially supported by a pharmaceutical company producing venlafaxine