Degree | CYTOTOXICITY | CULTURE CONDITIONS |
0 | Absent | Discontinuous cytoplasmic granules; without cell lysis |
1 | Slight | Up to 20% of cells are vaguely round, without cytoplasmic granules; lysed cells are occasionally present |
2 | Mild | Up to 50% of cells are round, devoid of cytoplasmic granules, without extensive cellular lysis, and with empty areas between cells |
3 | Moderate | Up to 70% of layers contain rounded or lysed cells |
4 | Severe | Almost complete destruction of cellular layers |