Hematological diagnosis

N

Hb (g/dl)

Epo (mIU/ml)

log-Epo

RAI

p

p^#

x ± SD

Median (range)

x ± SD

x ± SD

Non anemic subjects

54

13.9 ± 1.5

12.3 (3.7 - 30.9)

1.10 ± 0.18

15.2 ± 2.3

*

Normal controls

36

14.1 ± 1.2

13.6 (6.8 - 30.9)

1.14 ± 0.16

16.1 ± 2.1

*

Diabetic non anemic subjects

18

13.7 ± 1.1

10.4 (3.7 - 20.6)

1.01 ± 0.21

13.7 ± 2.2

<0.001

Secondary erythrocytosis

34

17.5 ± 1.1

19.4 (11.5 - 90)

1.33 ± 0.22

23.3 ± 4.2

<0.001

<0.001

Iron-deficiency anemia

48

9.7 ± 1.5

54.1 (4.5 - 351)

1.69 ±0.48

15.8 ± 3.3

ns

ns

Megaloblastic anemia

56

7.7 ± 2.4

67.3 (9.4 - 280)

1.81 ± 0.38

13.2 ± 2.3

<0.001

<0.001

Anemia of chronic disease

34

10.4 ± 1.2

20.4 (6.6 - 102)

1.33 ± 0.28

13.7 ± 2.4

0.028

<0.001

Hemoglobinopathies

115

9.6 ± 1.1

59.2 (4.7 - 450)

1.80 ± 0.34

17.3 ± 3.3

<0.001

0.046

β-thalassemic trait

41

11.1 ± 1.4

17 (3.8 - 78.9)

1.25 ± 0.26

13.8 ± 2.6

0.008

<0.001

Aplastic anemia

20

9.4 ± 2.9

300 (17.2 - 1567)

2.29 ± 0.54

20.3 ± 3.6

<0.001

<0.001

Hemolytic & other anemias

30

10.3 ± 1.8

34.9 (8.1 - 315)

1.62 ± 0.47

16.2 ± 3.7

ns

ns

MDS-RA

102

9.5 ± 1.7

93.7 (9.4 - 837)

1.92 ± 0.45

17.7 ± 3.2

<0.001

0.007

MDS-RARS

46

9.0 ± 1.1

84.5 (15.3 - 587)

2.00 ± 0.44

17.8 ± 3.2

<0.001

0.009

MDS-RAEB

92

9.1 ± 1.3

120 (13.1 - 1130)

2.05 ± 0.44

18.4 ± 3.3

<0.001

<0.001

MDS-Other

21

8.9 ± 1.1

174 (14.5 - 385)

2.11 ± 0.44

18.5 ± 3.3

<0.001

<0.001

CMML and MDS/MPD

65

9.7 ± 1.6

47.5 (12.2 - 455)

1.77 ± 0.43

16.7 ± 2.7

0.003

ns

Polycythemia vera

38

17.0 ± 1.7

6.6 (1.9 - 13.7)

0.76 ± 0.22

12.8 ± 3.2

<0.001

<0.001

Essential thrombocythemia

62

13.0 ± 2.2

12.9 (3.5 - 196)

1.18 ± 0.35

14.9 ± 3.0

ns

0.034

Myelofibrosis

32

9.4 ± 2.0

72.1 (7 - 2670)

1.92 ± 0.56

17.0 ± 2.8

0.003

ns

Chronic myeloidleukemia

18

10.6 ± 2.0

39.8 (11 - 201)

1.61 ± 0.33

16.6 ± 2.6

ns

ns

Acute myeloidleukemia

23

9.6 ± 2.2

48.6 (11.5 - 338)

1.88 ± 0.48

17.2 ± 2.8

0.003

ns

Non Hodgkin’s lymphoma

34

10.4 ± 2.2

31.6 (8.8 - 262)

1.54 ± 0.35

15.6 ± 2.4

ns

ns

Chronic lymphoid leukemia

30

11.7 ± 2.3

25.5 (8.0 - 288)

1.48 ± 0.41

16.7 ± 2.2

0.008

ns

Plasma-cell dyscrasias

79

9.7 ± 1.8

44.1 (8.0 - 326)

1.65 ± 0.35

16.1 ± 3.3

ns

ns

Other lyphoprolif. disorders

18

11.3 ± 2.7

30.3 (8.5 - 315)

1.59 ± 0.44

17.1 ± 3.6

0.017

ns

Total subjects tested

1096

10.6 ± 2.8

41.5 (2.3 - 2670)

1.67 ± 0.52

16.6 ± 3.8