Disease specific survival

Time to relapse

Survival %

n = 2005

Univariate p value

Multivariate

P value (HR [95% CI])

Survival %

n = 2005

Univariate p value

Multivariate P value (HR [95% CI])

Gender

Female

Male

82.0

78.6

0.123

76.7

74.4

0.269

Age

≤70

>70

81.7

78.1

0.001

0.004 (1.5 [1.1 - 1.9])

70.6

80.3

<0.001

Diagnosis

Adenocarcinoma

Other cancer

80.2

60.9

0.007

74.7

50.0

0.002

Metastasis at presentation

No

Yes

75.8

56.7

<0.001

Neo adjuvant CT

No

Yes

81.4

72.3

0.003

77.2

60.9

<0.001

Neo adjuvant RT

No

Yes

81.1

75.8

0.119

76.9

63.5

<0.001

Adjuvant CT

No

Yes

86.8

71.1

<0.001

83.0

66.4

<0.001

Adjuvant RT

No

Yes

81.8

45.1

<0.001

76.2

62.5

0.009

Relapse

No

Yes

91.6

43.0

<0.001

<0.001 (12.6 [8.9 - 17.8])

-

-

T stage

T1

T2

T3

T4

93.0

91.5

79.2

75.0

<0.001

87.5

88.1

77.4

58.9

<0.001

N stage

N0

N1

N2

90.4

78.3

60.3

<0.001

83.7

72.9

58.0

<0.001

Dukes stage

A^R

B

C1

C2/D

92.7

85.9

71.1

55.1

<0.001

0.019 (1.9 [1.1 - 3.5])

<0.001 (4.2 [2.5 - 7.3])

<0..01 (9.1 [5.0 - 16.8])

87.9

78.8

68.3

56.1

<0.001

0.047 (1.6 [1.0 - 2.6])

0.009 (1.9 [1.2 - 3.2])

<0.001 (2.9 [1.6 - 5.2])

Treatment

Surgery only

Surgery + CT

Surgery + RT

Surgery + RT + CT

88.3

73.4

63.6

71.6

<0.001