BARD1

CYP2D6

FLT3

LMO1

PARP1

RHOA

TOP2A

BAX

CYP3A4*4

FLT4

LRP1B

PARP2

RICTOR

TP53

BCL2

CYP3A5

FOXA1

LYN

PAX5

RNF43

TP63

BCL2L11(BIM)

CYSLTR2

FOXL2

LZTR1

PBRM1

ROS1

TPMT

BCR

DAXX

FOXP1

MAP2K1(MEK1)

PDCD1(PD1)

RPTOR

TSC1

BIRC3

DDR2

FRG1

MAP2K2(MEK2)

PDCD1LG2(PD-L2)

RRM1

TSC2

BLM

DENND1A

GATA1

MAP2K4

PDE11A

RUNX1

TSHR

BMPR1A

DHFR

GATA2

MAP3K1

PDGFRA

RUNX1T1

TTF1

BRAF

DICER1

GATA3

MAP3K4

PDGFRB

SBDS

TUBB3

BRCA1

DLL3

GATA4

MAX

PDK1

SDC4

TYMS

BRCA2

DNMT3A

GATA6

MCL1

PGR

SDHA

U2AF1

BRD4

DOT1L

GNA11

MDM2

PHOX2B

SDHB

UGT1A1

BRIP1

DPYD

GNAQ

MDM4

PIK3C3

SDHC

VAMP2

BTG2

DTL(CDT2)

GNAS

MECOM

PIK3CA

SDHD

VEGFA

BTK

DUSP2

GRIN2A

MED12

PIK3CD

9-Sep

VHL

BUB1B

EGFR

GRM3

MEF2B

PIK3R1

SETBP1

WAS

c11orf30

EIF1AX

GRM8

MEN1

PIK3R2

SETD2

WISP3

CASP8

EP300

GSTM1

MET

PKHD1

SF3B1

WRN

CBL

EPAS1

GSTM4

MGMT

PLAG1

SGK1

WT1

CBLB

EPCAM

GSTP1

MITF

PLCB4

SKP2

XPA

CCND1

EPHA2

GSTT1

MLH1

PLK1

SLC34A2

XPC

CCNE1

EPHA3

HDAC2

MLH3

PMS1

SLC3A2

XRCC1

CD274(PD-L1)

EPHA5

HDAC9

MLLT1

PMS2

SMAD2

XRCC2

CD74

ERBB2(HER2)

HGF

MLLT3

POLD1

SMAD3

YAP1

CDA

ERBB2IP

HLA-A

MLLT4

POLD3

SMAD4

ZNF217

CDC73

ERBB3

HNF1A

MPL

POLE

SMAD7

ZNF703

CDH1

ERBB4

HNF1B

MRE11A

POLH

SMARCA4

CDK10

ERCC1

HRAS

MSH2

POT1

SMARCB1

Key genes for targeted drug use

Key genes for chemotherapy

Genetic risk prediction genes

Important tumor-driving genes, but there are no targeted drugs at present

Key genes in the tumor-related signaling pathways