Genes | Variations | Mutant types | Ways of mutation | Possible functions |
EP300 | p.M153V | c.457A > G(p.M153V) | Missense mutation in exon 2 (33% in MF*) | Possible tumor driving genes |
DPYD | p.I153V | c.1627A > G(p.I153V) | Heterozygous polymorphism | Side effects may increase for drugs of 5-FU, capecitabine, etc. |
ERCC1 | p.N118N | c.354T > C(p.N118=) | Heterozygous polymorphism | The curative effect by using drugs of platinum may be better than that of the wild type. |
NQO1 | p.P187S | c.559C > T(p.P187S) | Heterozygous polymorphism | The curative effect by using mitomycin C may be worse than that of the wild type. |
TPMT | p.Y240C | c.719A > G(p.Y240C) | Heterozygous polymorphism | Toxic side effects by using mercaptopurine may increase |
XRCC1 | p.Q399R | c.1196A > G(p.Q399R) | Heterozygous polymorphism | The curative effect by using drugs of platinum may be better than that of the wild type. |