Study

Sample Size

Tumor Type

Duration of Follow-Up

Number (%) with Radiation Retinopathy at End of Follow-Up

Predictors of Radiation Retinopathy after Treatment

Sagoo et al. 2007 [10]

37 patients

Circumpapillary choroidal melanoma

Mean 52 months, median 46 months

7/37 (18.9%) with proliferative retinopathy

--

Sagoo et al. 2008 [11]

141 patients

Juxtapapillary choroidal melanoma overhanging optic disc

Mean 56 months

61 (43.3%) patients with nonproliferative retinopathy, 26 patients (18.4%) progressed to proliferative retinopathy by the end of follow-up

--

Correa et al. 2009 [41]

120 patients

Choroidal melanoma treated with iodine-125 brachytherapy

--

7.5% with retinopathy

--

Bianciotto et al. 2010 [42]

3841 patients

Choroidal melanoma

--

138/3841 (3.6%) with proliferative retinopathy

Young age, diabetes mellitus, shorter tumor distance to optic disc

Finger et al. 2010 [30]

384 patients

Uveal melanomas treated with Palladium-103

Mean 47.2 months

Maculopathy in 8% of patients with anterior tumor and 41% of patients with posterior tumor

Posterior location, tumor height > 6.0 mm

Verschueren et al. 2010 [13]

430 patients

Choroidal melanoma

Median 50 months

56/430 (13.0%) with retinopathy; 65/430 (15.1%) with maculopathy

--

Newman et al. 2011 [15]

50 patients

Subfoveal choroidal melanomas with ≥6 months of follow-up

Median 54 months

28/50 (56%) with retinopathy; Stage 1: None; Stage 2: 14%; Stage 3: 54%; Stage 4: 32%

--

Finger et al. 2012 [16]

24 patients

Choroidal melanomas within 1.5 mm of optic disc treated with slotted radiotherapy

Mean 23 months

9/24 (37.5%) with maculopathy

--

Berry et al. 2013 [17]

82 patients

Medium sized choroidal melanomas

Median 46.8 months

31/82 (37.8%) with retinopathy

--

Krema et al. 2013 [38]

30 patients

Posterior tumor margin 0 - 2.5 mm from optic disc

--

60% with retinopathy

--

Semenova et al. 2013 [19]

72 patients

Small choroidal melanomas

Mean 54 months

31/72 (43.1%) with maculopathy

--

Sagoo et al. 2014 [32]

650 eyes

Juxtapapillary choroidal melanoma

Median 40 months

Nonproliferative retinopathy at 5 years: 66%; Proliferative retinopathy at 5 years: 24%; Maculopathy at 5 years: 56%

Nonproliferative: Hypertension; Proliferative: Mean tumor thickness;

Maculopathy: Visual acuity > 20/60 at presentation

Semenova et al. 2014 [20]

47 patients

T3 or T4 sized choroidal melanomas treated with palladium brachytherapy

Median 47 months

31/47 (66%) with retinopathy

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