Study

Sample Size

Tumor Type

Duration of Follow-Up

Number (%) Requiring Enucleation for Tumor Recurrence by End of Follow-Up

Number (%) Requiring Enucleation for Treatment Side Effects by End of Follow-Up

Total Number (%) Requiring Enucleation

Predictors of Requiring Enucleation after Treatment

Bergman et al. 2005 [29]

579 eyes

Choroidal and ciliary body melanomas

3 and 5 years

60/579 (10.4%) at 3 years

17/579 (2.9%) at 3 years

106 patients enucleated total with cumulative incidence 16.8%

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Sagoo et al. 2007 [10]

37 patients

Circumpapillary choroidal melanoma

Mean 52 months, median 46 months

3/37 (8.1%)

4/37 (10.8%)

7/37 (18.9%)

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Sagoo et al. 2008 [11]

141 patients

Juxtapapillary choroidal melanoma overhanging optic disc

Mean 56 months

7/141 (5.0%)

20/141 (14.2%)

27/141 (19.1%)

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Finger et al. 2010 [30]

384 patients

Uveal melanomas treated with palladium-103 brachytherapy

Mean 47.2 months

--

--

11/384 (2.9%) within 3 years

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Gunduz et al. 2010 [12]

24 patients

Choroidal melanoma treated with ruthenium brachytherapy alone

--

--

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2/15 (13.3%) for tumors ≤5 mm, 1/9 (11.1%) for tumors >5 mm to <8 mm

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Verschueren et al. 2010 [13]

430 patients

Choroidal melanoma

Median 50 months

10/430 (2.3%)

7/430 (1.6%)

17 (4.4%)

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