RTOG/EORTC toxicity scale

Grade 1

Grade 2

Grade 3

Grade 4

GI acute toxicity

Increased frequency or change in quality of

bowel habits not requiring medication;

rectal discomfort not requiring analgesics

Diarrhoea requiring

parasympatholytic

drugs; mucous discharge not

necessitating sanitary pads; rectal or abdominal pain requiring analgesics

Diarrhoea requiring

parenteral support;

severe mucous or blood discharge

necessitating sanitary pads; abdominal distension (flat plate radiograph demonstrates distended bowel loops)

Obstruction.

fistula or perforation; GI bleeding requiring

transfusion; abdominal pain or

tenesmus requiring tube decompression or bowel diversion

GI late toxicity

Mild diarrhoea; mild cramping; bowel

movements 2 - 5

per day; slight

rectal discharge

or bleeding

Moderate diarrhoea;

Intermittent severe cramping; bowel movements >5 per day; moderate

excessive rectal

discharge; intermittent.

frequent bleeding

®single laser

treatment and/ or

transfusion

Watery diarrhoea;

obstruction

requiring surgery;

bleeding requiring

surgery or 2

laser treatments

and/or transfusions

Necrosis; perforation; fistula;

abdominal pain or tenesmus requiring tube decompression

or bowel diversion