| Intervention Name | Strategies or Activities | Setting | Target Population | Outcomes | Program Status | |
| 1. Red Cross Blood Services Free Sickle Cell Trait Screening [29] (2023) | · A recent intervention by the Red Cross has expanded its testing to include sickle cell trait screening on all donations from self-identified African American donors. · This additional screening will help the Red Cross identify compatible blood types more quickly to help sickle cell patients and provide Black donors this important health insight. · African American donors can opt out of the screening if they wish. · Upon receiving a positive screening result, donors are directed to the Red Cross website to learn more about sickle cell trait and are encouraged to follow up with their healthcare provider. | Red Cross Centers across the United States from 2023 to present day. | All self-identified African American blood donors. | This intervention has not been evaluated and outcomes have not been reported. | This intervention is active. | |
| 2. As One Foundation Operation Hydration [51] | · A signature training program that teaches student athletes, coaches, training staff and parents about sickle cell trait awareness, hydration, and prevention of sports-related deaths. · Seeks to create earlier awareness of the correlation between sickle cell and lack of hydration—preventing sports related deaths due to dehydration and exhaustion. · Provides an annual training program for high school coaches, other athletic related staff as well as student athletes. | The As One Foundation is located in Florida and many Operation Hydration events happen in Florida, but it is a nationwide program. | Youth across the US, specific high school athletes, as only Division One college athletes undergo mandatory testing for sickle cell trait before participating in sports. | · Trainees are pre- and post-tested to measure the effectiveness of the training—outcomes include an 80% increase in awareness. | This intervention is active. | |
| 3. 23andMe Sickle Cell Carrier Status Awareness Program [52] (2022) | · Partnership between 23andMe and various sickle cell trait organizations to provide free testing and awareness. · 23andMe is collaborating with Breaking the Sickle Cell Cycle on a Sickle Cell Carrier Status Awareness Program that offers free 23andMe Health + Ancestry kits to participants and provides education and counseling services. | Nationwide, limited to people in the United States. The intervention began in 2022, and is active today. | People who do not know their sickle cell trait status who are over the age of 18. | · 23andMe does not report how many people in total they have tested for sickle cell trait, but 19,000 people in their database with sickle cell trait were part of the largest study of sickle cell trait to date that determined that people with sickle cell trait are at higher risk of experiencing pulmonary embolism [54] . | This intervention is active. | |
| 4. Kidney Cancer Association and Sickle Cell Disease Association of America (SCDAAA) KNOW & TELL [30] (2021-2022) | · KNOW & TELL aims to raise awareness of sickle cell trait and its link to RMC. · The year-long initiative seeks to promote the early identification of RMC by encouraging people to know their sickle cell trait status and inform their family and health care providers about the connection between sickle cell trait and RMC. | Nationwide, 2021-2023. | People who are at risk of having a sickle cell trait. | No outcomes were reported. | This intervention is no longer active—the initiative took place from 2021-2022, however the educational materials are still present on both the Kidney Cancer Association and SCDAAA websites. | |
| 5. Sickle Cell Disease Foundation Hemoglobin Trait Follow-Up Program [31] | · The Sickle Cell Disease Foundation (SCDF) is a certified sickle cell trait counseling center. In partnership with the California Department of Public Health, Division of Genetic Disease Screening-Newborn Screening Program the SCDF provides parents of infants identified with sickle cell trait, hemoglobin C trait, and hemoglobin D trait free trait counseling and family testing. | California. | Parents of infants who screen positive for sickle cell trait, hemoglobin C trait and hemoglobin D trait. | No outcomes have been reported. | This intervention is active. | |
| 6. Sickle Cell Disease Association of America Free sickle cell trait testing through local sickle cell organizations that are members of SCDAAA [32] | · SCDAAA partners with local sickle cell trait organizations such as SCDAAA chapters and state organizations (e.g., the Massachusetts Sickle Cell Association) to provide funding for tests. | Nationwide. | People at risk for having a sickle cell trait. | No outcomes have been reported. | This intervention is active. | |