a) First trimester

Quinine tab 300 mg three times daily for seven days, or if vomiting, administer quinine injection 20 mg/kg load doses, then maintenance dose of 10 mg/kg three times daily for 24 or 48 hours. Switch to oral if the patient tolerates it.

b) The second and third trimesters

Quinine tab 300 mg three times daily for seven days.

Management of severe malaria in pregnancy according to the national malaria guidelines

First-line drug according to the current national malaria treatment guidelines in the treatment of severe malaria in pregnancy.

a) First trimester

Artesunate injectable 2.4 mg/kg 0 doses, then 12 hours, 24 hours, and then switch to oral.

b) The second and third trimesters

Artesunate injectable 2.4 mg/kg 0 doses, then 12 hours, 24 hours, and then switch to oral.

The second drug option (if artesunate injectables are not available) according to the current national malaria treatment guidelines in the treatment of severe malaria in pregnancy.

c) First trimester

Quinine injection 20 mg/kg load doses then a maintenance dose of 10 mg/kg three times daily for 24 or 48 hrs. Switch to oral if the patient tolerates it.

d) The second and third trimesters

Quinine injection 20 mg/kg load doses then maintenance dose of 10 mg/kg three times for 24 or 48 hours. Switch to oral if the patient tolerates it.