animal | Gene knockout | Age/weight | BAV | Significant hemodynamic stenosis? | Histopathological changes of AV |
C57BL/6J background mice [95] | Chm-I | 8 and 20 weeks of age | Not known | Not known | Calcification, Neoangiogenesis, Lipid deposition |
in C57BL/6J but not 129S1/SvImJ mice [150] | EGFRWa2/Wa2 | ≤15 months | Not known | Yes, but background strain dependent | Cellular proliferation, ectopic cartilage for mation , extensive calcification, inflammatory infiltrate, Fibrosis |
mixed 129/SvEv×BALB/cBy background mice [96] | Madh6-/- | 4 - 6 months | Not known | Yes, may affect resistance vessels | Calcification, ossification, Excessive proliferation of mesenchymal cells |
C57BL/6 background mice [72] | MGPm1/MGPm1 (-/-) | After birth | Not known | Not known | Calcification |
C57BL/6J background mice [151] | eNOS-/- | 25 to 30 g/embryos at day 13.5 of gestation | Bicuspid aortic valves in0~40% of mice | Not known | Bicuspid aortic valves in0~40% of mice |
mice [152] | NOS3-/-; Notch1+/- | 6 - 8 weeks | Aortic valve malformations occur in nearly 100% of cases, the most common being BAV | highly penetrate BAV and develop hemodynamically significant aortic valve stenosis and regurgitation | Calcification, aortic valve malformations |
C57BL/6 background mice [153] | Notch1+/- | 10 months of age | No | No | Calcification |
N1+/− mTRWT mice (generation 1-3) [92] | Notch+/-mTRG2 | ≥1.5 months | Not known | No | Calcification |
mice [91] | Notch1 (mutation) | After birth | Relevant, specific data cannot be speculated | Not known | Calcification, Bicuspid aortic valves |
C57BL/6 background mice [90] | Postn-/- | 6 or 10 months | Not known | Not known | Calcification, Fibrosis |
C57BL/6 background mice [154] | Postn-/- | 12 weeks | Not known | No | Reduced valve thickening, Calcification, fibrosis |