Company

Target products

Classes

Products and market

Commercial interest

BASF http://www.corporate.basf.com/

Enzymes

Amylase Hydratase

Acidophilic gluco amylase

Food industry, aiding with the digestion of starch

Bioresearch Italia, SpA (Italy)

Anti-infectives

Vancomycin

Dalbavancin

Development of human gene targeted therapeutics and novel anti-infective

B.R.A.I.N

http://www.brain-biotech.de/

Bioactive

peptides and enzymes for

pharmaceuticals

and agrochemicals

N.D.

Nitrile hydratases

Cellulases

Degussa AG Partnership for the industrial processe

Cubist pharmaceuticals

https://www.merck.com/

Anti-infectives

N.D.

N.D.

Various commercial relationships.

Variety of products in Stage I, II and III trials

Diversa

http://www.diversa.com/

Enzymes

Nitrilase

Glycosidase

Phytase

Discovery of 100 novel nitrilases Production of Lipitor Pyrolasee 160 and Pyrolasee 200; Phyzymee XP

Drug, lowering cholesterol levels

Broad spectrum b-mannanase and b-glucanase added to animal feed to break down indigestible phytate in grains and oil s eeds to release digestible

Biometabolites

Fluorescent protein

Discovery Pointe Green-F P* and Cyan-FP*

Novel green and cyan flu orescent proteins for potential u se in drug discovery, ommercial screening and academic research

Diversa and Invitrogen

https://www.thermofisher.cn/cn/zh/home.html

Enzymes

DNA polymerase

hermal Acee and Replicasee DNA for research and diagnostics

Research and diagnostics

EMetagen

Enzymes;

antibiotics; small active molecules

Polyketides

eMetagen Gene and Pathway Banks eLarge clone DNA libraries

encoding biosynthetic pathways for 5000 to 20,000 secondary metabolites

Food, agriculture, research and other commercial applications Pharmaceuticals: antimicrobial, anticancer and other bioactive properties

Kosan Technology

http://www.kosan.com/

Antibioti cs

Polyketides

Adriamycin, Erythromycin, Meva-cor, Rapamycin, Tacrolimus (FK506), Tetracycl ine, Rapamyc in,

Therapeutic drugs

Genencor

http://www.genencor.com/

Enzymes

Lipase, Protease

Washing powder and alkaline tolerant protease.

Cleaning industry

Libragen

http://www.libragen.com/

Antibiotics and

biocatalysis for

pharmace uticals

N.D.

Anti-infective and antibiotic discovery Biocatalysis discovery for pharmaceuticals (partnership with Synkem)

Medicine; synthesis of pharmaceuticals

Prokaria

http://www.prokaria.is/

Enzymes

Rhamnosidase

b-1,6 Gluconase;

Single stranded DNA ligase

Food and agricultural industry

Food industry