Classification of TF families

Candidate transcription factors



Bacterial histone-like protein family

Integration host factor subunit alpha,


− A specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control

Fur family

Ferric uptake regulation protein


− Acts as a repressor, employing Fe2+ as a cofactor to bind the operator of the iron transport operon, Involved in exotoxin a regulation, siderophore regulation and manganese susceptibility, transcriptional activator activity and sequence-specific DNA binding

matp family

Macrodomain Ter protein


− Required for spatial organization of the terminus region of the chromosome (Termacrodomain) during the cell cycle.

− Prevents early segregation of duplicated Termacrodomains during cell division

− Binds specifically to matS, which is a 13 bp signature motif repeated within the Termacrodomain.

sigma-5 factor family

RNA polymerase sigma-54 factor


− Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released