Robust (n = 71)

Prefrail (n = 71)

Frail (n = 57)

P-value*

Current age (years), n (%)

[50 - 59]

53 (74.65)

40 (56.34)

25 (43.86)

0.001^*

[60 - 69]

17 (23.94)

23 (32.39)

19 (33.33)

≥70

1 (1.41)

8 (11.27)

13 (22.81)

Age at ART inclusion (years)

<50

64 (90.14)

50 (70.42)

39 (68.42)

0.002^*

≥50

7 (9.86)

21 (29.58)

18 (31.58)

Sex, n (%)

Women

40 (56.34)

51 (71.83)

35 (61.4)

0.15

Men

31 (43.66)

20 (28.17)

22 (38.6)

HIV profile, n (%)

1

70 (98.6)

61 (85.9)

47 (82.46)

0.007^*

2

1 (1.41)

9 (12.7)

8 (14.04)

1 + 2

-

1 (1.41)

2 (3.51)

Line of traitement, n (%)

First

68 (95.77)

68 (95.77)

54 (94.74)

0.93

Second

3 (4.23)

3 (4.23)

2 (3.51)

Third

-

-

1 (1.75)

WHO stage OMS at inclusion

I

20(28.17)

22 (30.99)

10 (17.54)

0.27

II

22 (30.99)

17 (23.94)

14 (24.56)

III

24 (33.8)

27 (38.03)

23 (40.35)

IV

5 (7.04)

5 (7.04)

10 (17.54)

Nadir TCD4+ Lymphocyte counts (elements/mm³)

<200

41 (57.75)

41 (57.75)

29 (50.88)

0.67

≥200

30 (42.25)

30 (42.25)

28 (4912)

Duration under ART (months)

<120

11 (15.49)

13 (18.31)

11 (19.3)

0.34

120 - 240

55 (77.46)

51 (71.83)

36 (63.16)

>240

5 (7.04)

7 (9.86)

10 (17.54)

Current therapeutic regimen

Without TDF

3 (4.23)

2 (2.82)

1 (1.75)

0.04^*

With TDF

68 (95.77)

69 (97.18)

56 (98.25)

Duration of TDF exposure

<10 years

52 (73.24)

55 (77.46)

7 (12.28)

0.001^*

>10 years

19 (26.76)

16 (22.54)

50 (87.72)

Current WHO stage

I

70 (98.59)

70 (98.59)

54 (94.74)

0.79

II

1 (1.41)

1 (1.41)

1 (1.75)

III

-

-

1 (1.75)

IV

-

-

1 (1.75)

Current viral load (copies/ml)

<40

71 (100)

70 (98.59)

55 (96.59)

0.28

>40

-

1 (1.41)

2 (3.51)

Body mass index

Underweight

5 (7.04)

6 (8.45)

8 (14.04)

0.29

Normal

33 (46.48)

27 (38.03)

31 (54.39)

Overweight/obesity

33 (46.48)

38 (53.53)

18 (31.58)

Sensory disorders

No

71 (100)

64 (90.14)

47 (82.46)

0.001^*

Yes

-

7 (9.86)

10 (17.54)

Comorbidities

<1

45 (63.38)

38 (53.52)

35 (61.4)

0.65

1 - 2

18 (25.35)

19 (26.76)

14 (24.55)

≥3

8 (11.27)

14 (19.72)

8 (14.04)

Charlson comorbidity Index

<1

52 (73.24)

44 (61.97)

37 (64.91)

0.69

1 - 2

11 (15.49)

15 (21.13)

11 (19.3)

≥3

8 (11.27)

12 (16.9)

9 (15.79)

Polypharmacy

≤4

58 (81.69)

45 (63.38)

34 (59.65)

0.013^*

≥5

13 (18.31)

26 (36.62)

23 (40.35)

MNA

Normal

63 (88.73)

55 (77.46)

16 (28.07)

0.001^*

Risk of malnutrition

8 (11.27)

16 (22.54)

35 (61.40)

Malnourished

-

-

6 (10.53)