Tubulopathy

Physiopathological state caused by acute renal failure

Biochemical and immunological factors

Damage to the

dilution-concentration capacity

Sodium overload

Atrial natriuretic factor

Decreased sodium

reabsorption

Hyperuricemia, hypercreatininaemia

Prostaglandins, prostacyclins, thromboxane A2, endothelins,

Leakage of potassium, magnesium and phosphorus

Hyperkalemia, metabolic acidosis

Macrophage Infiltrate

Decrease in H+ ions secretion in urine

Dilutional hyponatraemia

Increase in PAF and cytokines

Insensitivity to ADH